Effect of pneumonectomy on the remaining lung in dogs

R. L. Johnson, S. S. Cassidy, R. Grover, M. Ramanathan, A. Estrera, R. C. Reynolds, R. Epstein, J. Schutte

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

To determine the magnitude of functional compensation after pneumonectomy and whether compensation is related to maturity of the animal at the time of resection, we performed left pneumonectomy in either adult or 10-wk-old beagles. Studies were performed in adults 7-9 mo after surgery and in puppies 18-23 mo after surgery when the dogs reached full maturity. Results were compared with those in age- and sex-matched unoperated controls. Measurements included pressure-volume relationships, pulmonary hemodynamics, rebreathing studies of lung volume, diffusing capacity and its components, lung tissue volume, and pulmonary blood flow. Computerized-tomographic scans were performed in the puppy groups to determine changes in thoracic shape and size. Morphometric analysis of the lungs was performed under light microscopy. There was partial compensation for loss of one lung by functional improvement in the remaining lung. Compensation was greater in those pneumonectomized as puppies than as adults. Volume of the remaining lung was larger than predicted for a given transpulmonary pressure in both groups. Diffusing capacity, pulmonary capillary blood volume, and lung tissue volume were larger than expected for the normal right lung. After pneumonectomy, compliance of the rib cage was greater in puppies than in adults. Weight of the costal diaphragm was reduced in pneumonectomized puppies. Pulmonary hypertension at rest did not develop, and pulmonary vascular reactivity to hypoxia was unchanged after pneumonectomy in both groups. Significant correlations were obtained between physiological and morphometric measurements.

Original languageEnglish (US)
Pages (from-to)849-858
Number of pages10
JournalJournal of applied physiology
Volume70
Issue number2
DOIs
StatePublished - 1991

Keywords

  • computerized-tomographic scan
  • diaphragm
  • diffusing capacity
  • lung tissue volume
  • lung volume
  • maturity
  • membrane diffusing capacity
  • morphometry
  • pulmonary arterial pressure
  • pulmonary blood flow
  • pulmonary capillary blood volume
  • pulmonary vascular resistance
  • thoracic dimensions

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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  • Cite this

    Johnson, R. L., Cassidy, S. S., Grover, R., Ramanathan, M., Estrera, A., Reynolds, R. C., Epstein, R., & Schutte, J. (1991). Effect of pneumonectomy on the remaining lung in dogs. Journal of applied physiology, 70(2), 849-858. https://doi.org/10.1152/jappl.1991.70.2.849