Effect of pneumonectomy on the remaining lung in dogs

R. L. Johnson, S. S. Cassidy, R. Grover, M. Ramanathan, A. Estrera, R. C. Reynolds, R. Epstein, J. Schutte

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

To determine the magnitude of functional compensation after pneumonectomy and whether compensation is related to maturity of the animal at the time of resection, we performed left pneumonectomy in either adult or 10-wk-old beagles. Studies were performed in adults 7-9 mo after surgery and in puppies 18-23 mo after surgery when the dogs reached full maturity. Results were compared with those in age- and sex-matched unoperated controls. Measurements included pressure-volume relationships, pulmonary hemodynamics, rebreathing studies of lung volume, diffusing capacity and its components, lung tissue volume, and pulmonary blood flow. Computerized-tomographic scans were performed in the puppy groups to determine changes in thoracic shape and size. Morphometric analysis of the lungs was performed under light microscopy. There was partial compensation for loss of one lung by functional improvement in the remaining lung. Compensation was greater in those pneumonectomized as puppies than as adults. Volume of the remaining lung was larger than predicted for a given transpulmonary pressure in both groups. Diffusing capacity, pulmonary capillary blood volume, and lung tissue volume were larger than expected for the normal right lung. After pneumonectomy, compliance of the rib cage was greater in puppies than in adults. Weight of the costal diaphragm was reduced in pneumonectomized puppies. Pulmonary hypertension at rest did not develop, and pulmonary vascular reactivity to hypoxia was unchanged after pneumonectomy in both groups. Significant correlations were obtained between physiological and morphometric measurements.

Original languageEnglish (US)
Pages (from-to)849-858
Number of pages10
JournalJournal of Applied Physiology
Volume70
Issue number2
StatePublished - 1991

Fingerprint

Pneumonectomy
Dogs
Lung
Blood Volume
Pulmonary Diffusing Capacity
Pressure
Diaphragm
Pulmonary Hypertension
Compliance
Blood Vessels
Microscopy
Thorax
Hemodynamics
Light
Weights and Measures

Keywords

  • computerized-tomographic scan
  • diaphragm
  • diffusing capacity
  • lung tissue volume
  • lung volume
  • maturity
  • membrane diffusing capacity
  • morphometry
  • pulmonary arterial pressure
  • pulmonary blood flow
  • pulmonary capillary blood volume
  • pulmonary vascular resistance
  • thoracic dimensions

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Johnson, R. L., Cassidy, S. S., Grover, R., Ramanathan, M., Estrera, A., Reynolds, R. C., ... Schutte, J. (1991). Effect of pneumonectomy on the remaining lung in dogs. Journal of Applied Physiology, 70(2), 849-858.

Effect of pneumonectomy on the remaining lung in dogs. / Johnson, R. L.; Cassidy, S. S.; Grover, R.; Ramanathan, M.; Estrera, A.; Reynolds, R. C.; Epstein, R.; Schutte, J.

In: Journal of Applied Physiology, Vol. 70, No. 2, 1991, p. 849-858.

Research output: Contribution to journalArticle

Johnson, RL, Cassidy, SS, Grover, R, Ramanathan, M, Estrera, A, Reynolds, RC, Epstein, R & Schutte, J 1991, 'Effect of pneumonectomy on the remaining lung in dogs', Journal of Applied Physiology, vol. 70, no. 2, pp. 849-858.
Johnson RL, Cassidy SS, Grover R, Ramanathan M, Estrera A, Reynolds RC et al. Effect of pneumonectomy on the remaining lung in dogs. Journal of Applied Physiology. 1991;70(2):849-858.
Johnson, R. L. ; Cassidy, S. S. ; Grover, R. ; Ramanathan, M. ; Estrera, A. ; Reynolds, R. C. ; Epstein, R. ; Schutte, J. / Effect of pneumonectomy on the remaining lung in dogs. In: Journal of Applied Physiology. 1991 ; Vol. 70, No. 2. pp. 849-858.
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