Effect of postpartum HIV treatment discontinuation on long-term maternal outcome

Nur F. Önen, Diana Nurutdinova, Somnuek Sungkanuparph, Debra Gase, Kristin Mondy, E. Turner Overton

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Background. Long-term maternal outcomes after postpartum antiretroviral therapy (ART) discontinuation are unknown. Methods. Retrospective review of pregnancies in HIV-infected women on treatment between 1997 and 2005. Women were grouped by postpartum ART use and followed until new opportunistic infection (OI), death or last clinic visit. Results. Of 172 pregnancies, postpartum ART discontinuation occurred in 123 (71.5%) women and was associated with greater parity, no partner during pregnancy, and no indication for OI prophylaxis or preconception ART in multivariate analysis (P <.05). Median follow-up was 32.5 months after delivery. There were 12 OIs and 2 deaths; 10 OIs and both deaths occurred in women who had discontinued ART. Conclusion. Postpartum ART discontinuation is common, especially among those with less advanced HIV disease, but may leave women at increased risk of long term adverse outcomes. This study highlights the need for larger longitudinal studies to determine appropriate recommendations for postpartum ART administration.

Original languageEnglish (US)
Pages (from-to)245-251
Number of pages7
JournalJournal of the International Association of Physicians in AIDS Care
Volume7
Issue number5
DOIs
StatePublished - Sep 1 2008

Keywords

  • HIV
  • antiretroviral therapy discontinuation
  • maternal outcome
  • pregnancy

ASJC Scopus subject areas

  • Immunology
  • Dermatology
  • Infectious Diseases

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