TY - JOUR
T1 - Effect of potassium chloride on gastric acid secretion and gastrin release in humans
AU - FELDMAN, M.
AU - GOLDSCHMIEDT, M.
PY - 1992/8
Y1 - 1992/8
N2 - The effect of potassium chloride on gastric acid secretion and gastrin release was studied in 6 healthy human beings. On 3 separate days and in random order, subjects received an intragastric infusion of 0.5 L of a glucose‐saline solution to which had been added 40 mmol KCl, 40 mmol NaCl, or no additional salts. All test solutions stimulated acid secretion and gastrin release to a similar degree. While potassium ions play a critical role in acid secretion by parietal cells (via the H+, K+‐ATPase), KCl administered into the gastric lumen at a concentration of 80 mmol/L has no effect on acid secretion in man.
AB - The effect of potassium chloride on gastric acid secretion and gastrin release was studied in 6 healthy human beings. On 3 separate days and in random order, subjects received an intragastric infusion of 0.5 L of a glucose‐saline solution to which had been added 40 mmol KCl, 40 mmol NaCl, or no additional salts. All test solutions stimulated acid secretion and gastrin release to a similar degree. While potassium ions play a critical role in acid secretion by parietal cells (via the H+, K+‐ATPase), KCl administered into the gastric lumen at a concentration of 80 mmol/L has no effect on acid secretion in man.
UR - http://www.scopus.com/inward/record.url?scp=0026688305&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026688305&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2036.1992.tb00554.x
DO - 10.1111/j.1365-2036.1992.tb00554.x
M3 - Article
C2 - 1420734
AN - SCOPUS:0026688305
SN - 0269-2813
VL - 6
SP - 407
EP - 414
JO - Alimentary Pharmacology & Therapeutics
JF - Alimentary Pharmacology & Therapeutics
IS - 4
ER -