Effect of potassium chloride on gastric acid secretion and gastrin release in humans

M. FELDMAN, M. GOLDSCHMIEDT

Research output: Contribution to journalArticle

Abstract

The effect of potassium chloride on gastric acid secretion and gastrin release was studied in 6 healthy human beings. On 3 separate days and in random order, subjects received an intragastric infusion of 0.5 L of a glucose‐saline solution to which had been added 40 mmol KCl, 40 mmol NaCl, or no additional salts. All test solutions stimulated acid secretion and gastrin release to a similar degree. While potassium ions play a critical role in acid secretion by parietal cells (via the H+, K+‐ATPase), KCl administered into the gastric lumen at a concentration of 80 mmol/L has no effect on acid secretion in man.

Original languageEnglish (US)
Pages (from-to)407-414
Number of pages8
JournalAlimentary Pharmacology & Therapeutics
Volume6
Issue number4
DOIs
StatePublished - Aug 1992

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology
  • Pharmacology (medical)

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