TY - JOUR
T1 - Effect of potassium magnesium citrate on thiazide-induced hypokalemia and magnesium loss
AU - Ruml, L. A.
AU - Pak, C. Y C
N1 - Funding Information:
Supported in part by grants no. PO1-DK20543 and M01-RR00633 from the National Institutes of Health, Bethesda, MD.
PY - 1999
Y1 - 1999
N2 - · The study was performed to ascertain the value of potassium magnesium citrate, magnesium citrate, and potassium citrate in overcoming thiazide- induced hypokalemia and magnesium loss. Sixty-two healthy subjects were first administered hydrochlorothiazide, 50 mg/d. After 3 weeks of thiazide treatment (or earlier for potassium level ≤3.5 mEq/L), they were randomized to receive one of three drugs while continuing to receive thiazide-potassium magnesium citrate (49 mEq of potassium, 24.5 mEq of magnesium), magnesium citrate (24.5 mEq/d of magnesium), or potassium citrate (49 mEq/d of potassium). Outcome measures were changes in serum potassium and magnesium levels and urinary potassium, magnesium, pH, and citrate values. All three drugs increased serum potassium concentration compared with that resulting from thiazide alone. Potassium magnesium citrate increased serum potassium levels from 3.3 ± 0.2 to 3.8 ± 0.3 mEq/L (P < 0.001), potassium citrate increased serum potassium levels from 3.4 ± 0.4 to 3.9 ± 0.3 mEq/L (P < 0.001), and magnesium citrate from 3.4 ± 0.4 to 3.7 ± 0.3 mEq/L (P < 0.001). Potassium magnesium citrate led to a significant increase in urinary magnesium levels by the third week of supplementation (from 120 ± 34 to 149 ± 58 mg/d; P < 0.01) and produced a small but significant increase in serum magnesium level. Magnesium citrate significantly increased 24-hour urinary magnesium after the first week of supplementation and maintained this increase throughout the study. Potassium magnesium citrate and potassium citrate, but not magnesium citrate, significantly increased urinary pH and citrate values. Potassium magnesium citrate not only corrects thiazide- induced hypokalemia, but also may avert magnesium loss while providing an alkali load.
AB - · The study was performed to ascertain the value of potassium magnesium citrate, magnesium citrate, and potassium citrate in overcoming thiazide- induced hypokalemia and magnesium loss. Sixty-two healthy subjects were first administered hydrochlorothiazide, 50 mg/d. After 3 weeks of thiazide treatment (or earlier for potassium level ≤3.5 mEq/L), they were randomized to receive one of three drugs while continuing to receive thiazide-potassium magnesium citrate (49 mEq of potassium, 24.5 mEq of magnesium), magnesium citrate (24.5 mEq/d of magnesium), or potassium citrate (49 mEq/d of potassium). Outcome measures were changes in serum potassium and magnesium levels and urinary potassium, magnesium, pH, and citrate values. All three drugs increased serum potassium concentration compared with that resulting from thiazide alone. Potassium magnesium citrate increased serum potassium levels from 3.3 ± 0.2 to 3.8 ± 0.3 mEq/L (P < 0.001), potassium citrate increased serum potassium levels from 3.4 ± 0.4 to 3.9 ± 0.3 mEq/L (P < 0.001), and magnesium citrate from 3.4 ± 0.4 to 3.7 ± 0.3 mEq/L (P < 0.001). Potassium magnesium citrate led to a significant increase in urinary magnesium levels by the third week of supplementation (from 120 ± 34 to 149 ± 58 mg/d; P < 0.01) and produced a small but significant increase in serum magnesium level. Magnesium citrate significantly increased 24-hour urinary magnesium after the first week of supplementation and maintained this increase throughout the study. Potassium magnesium citrate and potassium citrate, but not magnesium citrate, significantly increased urinary pH and citrate values. Potassium magnesium citrate not only corrects thiazide- induced hypokalemia, but also may avert magnesium loss while providing an alkali load.
KW - Hypokalemia
KW - Magnesium depletion
KW - Potassium magnesium citrate
KW - Thiazide
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U2 - 10.1016/S0272-6386(99)70115-0
DO - 10.1016/S0272-6386(99)70115-0
M3 - Article
C2 - 10401023
AN - SCOPUS:0033058045
SN - 0272-6386
VL - 34
SP - 107
EP - 113
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
IS - 1
ER -