Effect of primary tumor extirpation in breast cancer patients who present with stage IV disease and an intact primary tumor

Gildy V. Babiera, Roshni Rao, Lei Feng, Funda Meric-Bernstam, Henry M. Kuerer, S. Eva Singletary, Kelly K. Hunt, Merrick I. Ross, Karin M. Gwyn, Barry W. Feig, Frederick C. Ames, Gabriel N. Hortobagyi

Research output: Contribution to journalArticle

196 Scopus citations

Abstract

Background: Currently, therapy for breast cancer patients with stage IV disease and an intact primary tumor is metastasis directed; the primary tumor is treated only when it causes symptoms. A recent review suggested that surgery may improve long-term survival in such patients. We evaluated the effect of surgery in such patients on long-term survival and disease progression. Methods: We reviewed the records of all breast cancer patients treated at our institution between 1997 and 2002 who presented with stage IV disease and an intact primary tumor. Information collected included demographics, tumor characteristics, site(s) of metastases, type/date of operation, use of radiotherapy, chemotherapy and hormonal therapy, disease progression (time to progression and location of progression) in the first year after diagnosis, and last follow-up. Overall and metastatic progression-free survival were compared between surgery and nonsurgery patients. Results: Of 224 patients identified, 82 (37%) underwent surgical extirpation of the primary tumor (segmental mastectomy in 39 [48%] and mastectomy in 43 [52%]), and 142 (63%) were treated without surgery. The median follow-up time was 32.1 months. After adjustment for other covariates, surgery was associated with a trend toward improvement in overall survival (P = .12; relative risk, .50; 95% confidence interval, .21-1.19) and a significant improvement in metastatic progression-free survival (P = .0007; relative risk, .54; 95% confidence interval, .38-.77). Conclusions: Removal of the intact primary tumor for breast cancer patients with synchronous stage IV disease is associated with improvement in metastatic progression-free survival. Prospective studies are needed to validate these findings.

Original languageEnglish (US)
Pages (from-to)776-782
Number of pages7
JournalAnnals of Surgical Oncology
Volume13
Issue number6
DOIs
StatePublished - Jun 1 2006

Keywords

  • Breast cancer
  • Metastasis
  • Outcome
  • Stage IV disease
  • Surgery
  • Synchronous stage IV disease

ASJC Scopus subject areas

  • Surgery
  • Oncology

Fingerprint Dive into the research topics of 'Effect of primary tumor extirpation in breast cancer patients who present with stage IV disease and an intact primary tumor'. Together they form a unique fingerprint.

  • Cite this

    Babiera, G. V., Rao, R., Feng, L., Meric-Bernstam, F., Kuerer, H. M., Singletary, S. E., Hunt, K. K., Ross, M. I., Gwyn, K. M., Feig, B. W., Ames, F. C., & Hortobagyi, G. N. (2006). Effect of primary tumor extirpation in breast cancer patients who present with stage IV disease and an intact primary tumor. Annals of Surgical Oncology, 13(6), 776-782. https://doi.org/10.1245/ASO.2006.03.033