Effect of propramolol on circadian variation of ventricular arrhythmias in elderly patients with heart disease and complex ventricular arrhythmias

Wilbert S. Aronow, Chul Ahn, Anthony D. Mercando, Stanley Epstein

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

In our elderly population with prior myocardial infarction or hypertensive heart disease, complex ventricular arrhythmias, and an LV ejection fraction ≥40%, a circadian variation of the maximal number of VPCs per hour was noted in patients before and after no antiarrhythmic drug and before propranolol. The primary peak occurred between 7a.m. and 12p.m. The secondary peak occurred between 6 and 9p.m. in patients before and after no antiarrhythmic drug and between 7 and 8p.m. in patients before treatment with propranolol. However, the circadian variation of the maximal number of VPCs per hour was markedly attenuated by propranolol. This suggests that the sympathetic nervous system contributes to the circadian variation of ventricular arrhythmias as well as to the circadian variation of myocardial infarction or sudden cardiac death.

Original languageEnglish (US)
Pages (from-to)514-516
Number of pages3
JournalThe American Journal of Cardiology
Volume75
Issue number7
DOIs
StatePublished - Mar 1 1995

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Propranolol
Cardiac Arrhythmias
Heart Diseases
Anti-Arrhythmia Agents
Myocardial Infarction
Sudden Cardiac Death
Sympathetic Nervous System
Population
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Effect of propramolol on circadian variation of ventricular arrhythmias in elderly patients with heart disease and complex ventricular arrhythmias. / Aronow, Wilbert S.; Ahn, Chul; Mercando, Anthony D.; Epstein, Stanley.

In: The American Journal of Cardiology, Vol. 75, No. 7, 01.03.1995, p. 514-516.

Research output: Contribution to journalArticle

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