Effect of propranolol versus no propranolol on total mortality plus nonfatal myocardial infarction in older patients with prior myocardial infarction, congestive heart failure, and left ventricular ejection fraction ≤40% treated with diuretics plus angiotensin-converting enzyme inhibitors

Wilbert S. Aronow, Chul Ahn, Itzhak Kronzon

Research output: Contribution to journalArticle

230 Citations (Scopus)

Abstract

At 32-month follow-up of older patients with prior myocardial infarction, congestive heart failure, and a left ventricular ejection fraction ≤40% treated with diuretics plus angiotensin-converting enzyme inhibitors, and also with digoxin if atrial fibrillation was present, propranolol caused a 35% significant reduction in total mortality and a 37% significant decrease in total mortality plus nonfatal myocardial infarction compared with no propranolol. At 1-year follow-up, propranolol caused a significantly greater increase in left ventricular ejection fraction (6%) and a significantly greater reduction in left ventricular mass (34 g) than did no propranolol (2% and 20 g, respectively).

Original languageEnglish (US)
Pages (from-to)207-209
Number of pages3
JournalAmerican Journal of Cardiology
Volume80
Issue number2
DOIs
StatePublished - Jul 15 1997

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Angiotensin-Converting Enzyme Inhibitors
Diuretics
Propranolol
Stroke Volume
Heart Failure
Myocardial Infarction
Mortality
Digoxin
Atrial Fibrillation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Effect of propranolol versus no propranolol on total mortality plus nonfatal myocardial infarction in older patients with prior myocardial infarction, congestive heart failure, and left ventricular ejection fraction ≤40{\%} treated with diuretics plus angiotensin-converting enzyme inhibitors",
abstract = "At 32-month follow-up of older patients with prior myocardial infarction, congestive heart failure, and a left ventricular ejection fraction ≤40{\%} treated with diuretics plus angiotensin-converting enzyme inhibitors, and also with digoxin if atrial fibrillation was present, propranolol caused a 35{\%} significant reduction in total mortality and a 37{\%} significant decrease in total mortality plus nonfatal myocardial infarction compared with no propranolol. At 1-year follow-up, propranolol caused a significantly greater increase in left ventricular ejection fraction (6{\%}) and a significantly greater reduction in left ventricular mass (34 g) than did no propranolol (2{\%} and 20 g, respectively).",
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T1 - Effect of propranolol versus no propranolol on total mortality plus nonfatal myocardial infarction in older patients with prior myocardial infarction, congestive heart failure, and left ventricular ejection fraction ≤40% treated with diuretics plus angiotensin-converting enzyme inhibitors

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AU - Ahn, Chul

AU - Kronzon, Itzhak

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AB - At 32-month follow-up of older patients with prior myocardial infarction, congestive heart failure, and a left ventricular ejection fraction ≤40% treated with diuretics plus angiotensin-converting enzyme inhibitors, and also with digoxin if atrial fibrillation was present, propranolol caused a 35% significant reduction in total mortality and a 37% significant decrease in total mortality plus nonfatal myocardial infarction compared with no propranolol. At 1-year follow-up, propranolol caused a significantly greater increase in left ventricular ejection fraction (6%) and a significantly greater reduction in left ventricular mass (34 g) than did no propranolol (2% and 20 g, respectively).

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