AIM: To investigate the mechanism of the fluency-based therapy on gastrointestinal motility in rats with acute pancreatitis (AP). METHODS: AP rats were induced by choledochal retrograde injection of 15 g/L sodium taurocholate 0.5 mL. The treatment group was administered with Qingyitang orally as a representative prescription of the fluency-based therapy and erythromycin given orally as a control group. The gastrointestinal motility, motilin, amylase and related parameters of AP were observed. We introduced the trace multi-channel calorstat from Japan to observe the contraction effect of Qingyitang on colon longitudinal muscle strips with different component of Qingyitang according to the orthogonal designed methods (L12(211)) in vitro. RESULTS: The drive rate of small intestine on AP group was significantly reduced (0.21±0.08, P <0.01) with Qingyitang (0.49±0.17) and erythromycin groups (0.30±0.10); The serum concentration of motilin (119±24 pg) in AP group was significantly lower than that of normal control group (169±52 pg, P <0.05), While the concentration of Qingyitang group (206±60 pg) was significantly higher than that of AP group (P <0.01). Besides, the pancreatitis mass edema, inflammatory cell infiltration and serum amylase were significantly decreased. Radix glehnine, Radix aucklandiae, Rhizoma corydalis and Radix et Rhizoma rhei of Qingyitang could increase the tension of the muscle strip in vitro (P < 0.05). CONCLUSION: The obstruction of gastrointestinal motility is an important pathologic process of AP, and Qingyitang as a representative prescription of the fluency-based therapy in traditional Chinese medicine, can improve the gastrointestinal motility in rats with AP.
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