Effect of restricting dietary protein on the progression of renal failure in patients with insulin-dependent diabetes mellitus

Kathleen Zeller, Elaine Whittaker, Lynn Sullivan, Philip Raskin, Harry R. Jacobson

Research output: Contribution to journalArticle

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Abstract

Background. Restriction of dietary protein may slow the progression of renal failure in diverse renal diseases, but the extent to which such a diet is beneficial in patients with diabetic nephropathy is uncertain. Methods. We studied the effect of reduced intake of protein and phosphorus on the progression of renal disease in 35 patients with insulin-dependent (Type I) diabetes mellitus and clinically evident nephropathy. The low-protein, low-phosphorus diet contained 0.6 g of protein per kilogram of ideal body weight per day, 500 to 1000 mg of phosphorus, and 2000 mg of sodium. The control diet consisted of the patient's prestudy diet with the stipulation that it contain 2000 mg of sodium and at least 1 g of protein per kilogram per day and 1000 mg of phosphorus. Renal function was assessed by measurement of iothalamate and creatinine clearances at intervals of 3 to 6 months, and the patients were followed for a minimum of 12 months (mean, 34.7). The declines in mean glomerular filtration rates were compared between groups by linear-regression analysis of the glomerular filtration rate as a function of time. Results. The patients who followed the study diet for a mean of 37.1 months had declines in iothalamate clearance of 0.0043 ml per second per month and in creatinine clearance of 0.0055 ml per second per month. The comparable values in the control group were 0.0168 and 0.0135, respectively (P<0.05). Blood pressure was well controlled, and the degree of glycemic control was comparable in both groups. Conclusions. Dietary restriction of protein and phosphorus can retard the progression of renal failure in patients with Type I diabetes mellitus who have nephropathy. We believe that wider use of this treatment is indicated.

Original languageEnglish (US)
Pages (from-to)78-84
Number of pages7
JournalNew England Journal of Medicine
Volume324
Issue number2
StatePublished - Jan 10 1991

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Dietary Proteins
Type 1 Diabetes Mellitus
Renal Insufficiency
Phosphorus
Iothalamic Acid
Diet
Glomerular Filtration Rate
Kidney
Creatinine
Dietary Phosphorus
Sodium
Ideal Body Weight
Protein-Restricted Diet
Proteins
Diabetic Nephropathies
Disease Progression
Linear Models
Regression Analysis
Insulin
Blood Pressure

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effect of restricting dietary protein on the progression of renal failure in patients with insulin-dependent diabetes mellitus. / Zeller, Kathleen; Whittaker, Elaine; Sullivan, Lynn; Raskin, Philip; Jacobson, Harry R.

In: New England Journal of Medicine, Vol. 324, No. 2, 10.01.1991, p. 78-84.

Research output: Contribution to journalArticle

Zeller, Kathleen ; Whittaker, Elaine ; Sullivan, Lynn ; Raskin, Philip ; Jacobson, Harry R. / Effect of restricting dietary protein on the progression of renal failure in patients with insulin-dependent diabetes mellitus. In: New England Journal of Medicine. 1991 ; Vol. 324, No. 2. pp. 78-84.
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