Untersuchung der rhG-CSF-Wirkung auf Plättchen mittels In-vitro-Blutungszeit und transkranieller Doppleruntersuchung.

Translated title of the contribution: Effect of rhG-CSF on platelets using in vitro bleeding time and transcranial Doppler examination

D. Söhngen, M. Siebler, S. Wienen, G. Kobbe, K. Hollmig, P. Schneider, C. Boogen, A. Heyll, W. Schneider

Research output: Contribution to journalArticlepeer-review

Abstract

There is experimental evidence for recombinant human granulocyte colony-stimulating factor (rhG-CSF)-induced stimulation of hemostaseologic parameters including platelets. Using the closure time of the in vitro bleeding test (IVBT, Thrombostat 4000, VDG, Seeon) and different hemostaseologic parameters, our results are suggestive of a directly or indirectly induced in vivo stimulation of platelets following rhG-CSF stimulation in healthy stem cell donors. According to the negative transcranial Doppler microembolic monitoring of the middle cerebral artery, there is no evidence for clinically silent cerebral microembolism supporting a prothrombotic state facilitating the formation of arterial thrombi with subsequent cerebral embolization.

Translated title of the contributionEffect of rhG-CSF on platelets using in vitro bleeding time and transcranial Doppler examination
Original languageGerman
Pages (from-to)161-165
Number of pages5
JournalBeiträge zur Infusionstherapie und Transfusionsmedizin = Contributions to infusion therapy and transfusion medicine
Volume34
StatePublished - 1997

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Effect of rhG-CSF on platelets using in vitro bleeding time and transcranial Doppler examination'. Together they form a unique fingerprint.

Cite this