Untersuchung der rhG-CSF-Wirkung auf Plättchen mittels In-vitro-Blutungszeit und transkranieller Doppleruntersuchung.

Translated title of the contribution: Effect of rhG-CSF on platelets using in vitro bleeding time and transcranial Doppler examination

D. Söhngen, M. Siebler, S. Wienen, G. Kobbe, K. Hollmig, P. Schneider, C. Boogen, A. Heyll, W. Schneider

Research output: Contribution to journalArticle

Abstract

There is experimental evidence for recombinant human granulocyte colony-stimulating factor (rhG-CSF)-induced stimulation of hemostaseologic parameters including platelets. Using the closure time of the in vitro bleeding test (IVBT, Thrombostat 4000, VDG, Seeon) and different hemostaseologic parameters, our results are suggestive of a directly or indirectly induced in vivo stimulation of platelets following rhG-CSF stimulation in healthy stem cell donors. According to the negative transcranial Doppler microembolic monitoring of the middle cerebral artery, there is no evidence for clinically silent cerebral microembolism supporting a prothrombotic state facilitating the formation of arterial thrombi with subsequent cerebral embolization.

Original languageGerman
Pages (from-to)161-165
Number of pages5
JournalBeiträge zur Infusionstherapie und Transfusionsmedizin = Contributions to infusion therapy and transfusion medicine
Volume34
StatePublished - 1997

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Bleeding Time
Granulocyte Colony-Stimulating Factor
Blood Platelets
Middle Cerebral Artery
Thrombin
Thrombosis
Stem Cells
Hemorrhage
In Vitro Techniques

Cite this

Untersuchung der rhG-CSF-Wirkung auf Plättchen mittels In-vitro-Blutungszeit und transkranieller Doppleruntersuchung. / Söhngen, D.; Siebler, M.; Wienen, S.; Kobbe, G.; Hollmig, K.; Schneider, P.; Boogen, C.; Heyll, A.; Schneider, W.

In: Beiträge zur Infusionstherapie und Transfusionsmedizin = Contributions to infusion therapy and transfusion medicine, Vol. 34, 1997, p. 161-165.

Research output: Contribution to journalArticle

Söhngen, D. ; Siebler, M. ; Wienen, S. ; Kobbe, G. ; Hollmig, K. ; Schneider, P. ; Boogen, C. ; Heyll, A. ; Schneider, W. / Untersuchung der rhG-CSF-Wirkung auf Plättchen mittels In-vitro-Blutungszeit und transkranieller Doppleruntersuchung. In: Beiträge zur Infusionstherapie und Transfusionsmedizin = Contributions to infusion therapy and transfusion medicine. 1997 ; Vol. 34. pp. 161-165.
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AU - Siebler, M.

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AU - Kobbe, G.

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AU - Boogen, C.

AU - Heyll, A.

AU - Schneider, W.

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