Effect of saline irrigation flow rate on temperature profile during cooled radiofrequency ablation

Wai Shun Wong, Brian A. Vanderbrink, Richard E. Riley, Mark Pomeranz, Mark S. Link, Munther K. Homoud, N. A. Mark Estes, Paul J. Wang

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Introduction: Cooled radiofrequency ablation has been developed clinically for the treatment of ventricular tachycardia. Although clinical studies employ a constant saline flow rate for cooling, we hypothesized that varying the flow rates might optimize the temperature profile at depth. Methods: In excised ovine left ventricle, we compared the temperature profile from a catheter tip electrode thermocouple to those placed at depths of 0.0 mm, 1.0 mm, and 2.0 mm. We compared the following settings: 20 Watts without flow, 20 Watts with 0.3 cc/sec flow, 20 Watts with 0.5 cc/sec flow, and 70°C surface temperature without flow (temperature control). Results: The temperatures decreased from 77.5 ± 10.5°C, 91.7 ± 6.3°C, 65.5 ± 11.8°C, and 52.5 ± 11.8°C at 20 W without saline irrigation at the tip, 0.0 mm, 1.0 mm, and 2.0 mm, respectively, to 33.0 ± 1.4°C*, 63.4 ± 7.0°C*, 57.1 ± 5.8°C*, 49.9 ± 5.8°C + at 20 W with 0.5 ml/sec flow (*p <0.01, +p = 0.09). The lesion volumes were 79.6 mm3 for 20 W without flow, 64.1 mm3 for 20 W with 0.3 ml/sec flow, 47.5 mm3 for 20 W with 0.5 ml/sec flow, and 28.6 mm3 for temperature control. Conclusions: We conclude that 1) the temperature profile greatly depends upon the rate of saline flow for cooling; 2) at high flow rates, the 0.0 mm and 1.0 mm temperatures are similar; 3) even at high irrigation rates, lesion size is greater than for temperature control; 4) the tip temperature significantly underestimates the surface temperature and improved methods of measuring temperature are needed.

Original languageEnglish (US)
Pages (from-to)321-326
Number of pages6
JournalJournal of Interventional Cardiac Electrophysiology
Volume4
Issue number1
StatePublished - May 13 2000

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Temperature
Ventricular Tachycardia
Heart Ventricles
Sheep
Electrodes
Catheters

Keywords

  • Ablation
  • Cooling
  • Lesion
  • Radiofrequency
  • Temperature

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Wong, W. S., Vanderbrink, B. A., Riley, R. E., Pomeranz, M., Link, M. S., Homoud, M. K., ... Wang, P. J. (2000). Effect of saline irrigation flow rate on temperature profile during cooled radiofrequency ablation. Journal of Interventional Cardiac Electrophysiology, 4(1), 321-326.

Effect of saline irrigation flow rate on temperature profile during cooled radiofrequency ablation. / Wong, Wai Shun; Vanderbrink, Brian A.; Riley, Richard E.; Pomeranz, Mark; Link, Mark S.; Homoud, Munther K.; Mark Estes, N. A.; Wang, Paul J.

In: Journal of Interventional Cardiac Electrophysiology, Vol. 4, No. 1, 13.05.2000, p. 321-326.

Research output: Contribution to journalArticle

Wong, WS, Vanderbrink, BA, Riley, RE, Pomeranz, M, Link, MS, Homoud, MK, Mark Estes, NA & Wang, PJ 2000, 'Effect of saline irrigation flow rate on temperature profile during cooled radiofrequency ablation', Journal of Interventional Cardiac Electrophysiology, vol. 4, no. 1, pp. 321-326.
Wong, Wai Shun ; Vanderbrink, Brian A. ; Riley, Richard E. ; Pomeranz, Mark ; Link, Mark S. ; Homoud, Munther K. ; Mark Estes, N. A. ; Wang, Paul J. / Effect of saline irrigation flow rate on temperature profile during cooled radiofrequency ablation. In: Journal of Interventional Cardiac Electrophysiology. 2000 ; Vol. 4, No. 1. pp. 321-326.
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AU - Vanderbrink, Brian A.

AU - Riley, Richard E.

AU - Pomeranz, Mark

AU - Link, Mark S.

AU - Homoud, Munther K.

AU - Mark Estes, N. A.

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AB - Introduction: Cooled radiofrequency ablation has been developed clinically for the treatment of ventricular tachycardia. Although clinical studies employ a constant saline flow rate for cooling, we hypothesized that varying the flow rates might optimize the temperature profile at depth. Methods: In excised ovine left ventricle, we compared the temperature profile from a catheter tip electrode thermocouple to those placed at depths of 0.0 mm, 1.0 mm, and 2.0 mm. We compared the following settings: 20 Watts without flow, 20 Watts with 0.3 cc/sec flow, 20 Watts with 0.5 cc/sec flow, and 70°C surface temperature without flow (temperature control). Results: The temperatures decreased from 77.5 ± 10.5°C, 91.7 ± 6.3°C, 65.5 ± 11.8°C, and 52.5 ± 11.8°C at 20 W without saline irrigation at the tip, 0.0 mm, 1.0 mm, and 2.0 mm, respectively, to 33.0 ± 1.4°C*, 63.4 ± 7.0°C*, 57.1 ± 5.8°C*, 49.9 ± 5.8°C + at 20 W with 0.5 ml/sec flow (*p <0.01, +p = 0.09). The lesion volumes were 79.6 mm3 for 20 W without flow, 64.1 mm3 for 20 W with 0.3 ml/sec flow, 47.5 mm3 for 20 W with 0.5 ml/sec flow, and 28.6 mm3 for temperature control. Conclusions: We conclude that 1) the temperature profile greatly depends upon the rate of saline flow for cooling; 2) at high flow rates, the 0.0 mm and 1.0 mm temperatures are similar; 3) even at high irrigation rates, lesion size is greater than for temperature control; 4) the tip temperature significantly underestimates the surface temperature and improved methods of measuring temperature are needed.

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KW - Lesion

KW - Radiofrequency

KW - Temperature

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