Effect of severity of pulmonary disease on nitrous oxide washin and washout characteristics?

P. Vichitvejpaisal, J. Liu, G. P. Joshi, P. F. White

Research output: Contribution to journalArticle

Abstract

The influence of chronic obstructive pulmonary disease (COPD) on the nitrous oxide (N2O) washin and washout characteristics was evaluated in 90 (ASA II-III) males undergoing elective peripheral surgery under general anaesthesia with controlled ventilation. Patients were classified by preoperative bedside pulmonary function testing into three groups. Group I (n=30), patients without COPD (FEV1/FVC > 80% predicted values; control group); Group H (n=30), patients with mild COPD (FEV1/FVC = 65-79% Of predicted values); and Group II (n=30), patients with moderate COPD (FEV1/FVC = 50-64% of predicted values). The anaesthetic technique was standardized for all patients. The Datex Capnomac Ultima(TM) monitor was used to measure the inspired and expired concentrations of nitrous oxide (N2O), carbon dioxide (CO2), and isoflurane. The duration of both N2O washin (time from start of N2O administration to equilibrium of inspired and expired N2O concentrations) and 5 per cent washout (time from discontinuation of N2O to an expired N2O concentration of 5 per cent of the equilibrium value) were recorded. The duration of N2O washin and washout were significantly Prolonged in Groups II and III (P < 0.001) as compared to the control group (Group I). The end-tidal CO2 concentration decreased significantly during N0 washout: without causing oxygen desaturation (Sp02 < 90%). We conclude that the duration of N20 washin and washout were significantly prolonged in anaesthetized patients with COPD which may delay the induction and recovery from H2O anaesthesia.

Original languageEnglish (US)
Pages (from-to)378-383
Number of pages6
JournalJournal of the Medical Association of Thailand
Volume80
Issue number6
StatePublished - 1997

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Nitrous Oxide
Lung Diseases
Chronic Obstructive Pulmonary Disease
Control Groups
Isoflurane
Carbon Dioxide
General Anesthesia
Ventilation
Anesthetics
Anesthesia
Oxygen
Lung

ASJC Scopus subject areas

  • Medicine(all)

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Effect of severity of pulmonary disease on nitrous oxide washin and washout characteristics? / Vichitvejpaisal, P.; Liu, J.; Joshi, G. P.; White, P. F.

In: Journal of the Medical Association of Thailand, Vol. 80, No. 6, 1997, p. 378-383.

Research output: Contribution to journalArticle

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