Effect of skeletal muscle fiber type on the pressor response evoked by static contraction in rabbits

L. B. Wilson, C. K. Dyke, D. Parsons, P. T. Wall, J. A. Pawelczyk, R. S. Williams, J. H. Mitchell

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The purpose of this study was to determine whether the reflex hemodynamic responses to static contraction of predominately glycolytic muscle are greater than the changes elicited by primarily oxidative muscle. Low- frequency electrical stimulation (continuous 21 days) of the tibial nerve of one hindlimb of adult rabbits converted the metabolic characteristics of the predominately glycolytic gastrocnemius to a muscle that was primarily oxidative. After 21 days of stimulation, the rabbits were decerebrated, and static contraction of the glycolytic muscle (unstimulated gastrocnemius) initially decreased heart rate (HR; -16 ± 3 beats/min) and mean arterial pressure (MAP; -17 ± 3 mmHg). Thereafter, MAP increased 13 ± 3 mmHg above baseline. Static contraction of the oxidative muscle (stimulated gastrocnemius/produced similar decreases in HR and MAP (-12 ± 4 beat/min and -12 ± 3 mmHg, respectively). However, the subsequent increase in MAP (8 ± 3 mmHg; above baseline) was less than that evoked by contraction of the glycolytic muscle. The responses evoked by stretch of each muscle and high- intensity electrical stimulation were the same, indicating that the afferents from the muscle were not destroyed by the chronic-stimulation technique. These results support the hypothesis that metabolic by-products play a role in the pressor response to static contraction of skeletal muscle. In addition, these data confirm that contraction of predominately oxidative muscle can evoke a reflex presser response, albeit smaller than the change elicited from primarily glycolytic muscle.

Original languageEnglish (US)
Pages (from-to)1744-1752
Number of pages9
JournalJournal of Applied Physiology
Volume79
Issue number5
StatePublished - 1995

Fingerprint

Skeletal Muscle Fibers
Rabbits
Muscles
Muscle Contraction
Skeletal Muscle
Electric Stimulation
Reflex
Tibial Nerve
Hindlimb
Arterial Pressure
Heart Rate
Hemodynamics

Keywords

  • decerebrate
  • exercise pressor reflex
  • glycolytic muscle
  • oxidative muscle

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Wilson, L. B., Dyke, C. K., Parsons, D., Wall, P. T., Pawelczyk, J. A., Williams, R. S., & Mitchell, J. H. (1995). Effect of skeletal muscle fiber type on the pressor response evoked by static contraction in rabbits. Journal of Applied Physiology, 79(5), 1744-1752.

Effect of skeletal muscle fiber type on the pressor response evoked by static contraction in rabbits. / Wilson, L. B.; Dyke, C. K.; Parsons, D.; Wall, P. T.; Pawelczyk, J. A.; Williams, R. S.; Mitchell, J. H.

In: Journal of Applied Physiology, Vol. 79, No. 5, 1995, p. 1744-1752.

Research output: Contribution to journalArticle

Wilson, LB, Dyke, CK, Parsons, D, Wall, PT, Pawelczyk, JA, Williams, RS & Mitchell, JH 1995, 'Effect of skeletal muscle fiber type on the pressor response evoked by static contraction in rabbits', Journal of Applied Physiology, vol. 79, no. 5, pp. 1744-1752.
Wilson LB, Dyke CK, Parsons D, Wall PT, Pawelczyk JA, Williams RS et al. Effect of skeletal muscle fiber type on the pressor response evoked by static contraction in rabbits. Journal of Applied Physiology. 1995;79(5):1744-1752.
Wilson, L. B. ; Dyke, C. K. ; Parsons, D. ; Wall, P. T. ; Pawelczyk, J. A. ; Williams, R. S. ; Mitchell, J. H. / Effect of skeletal muscle fiber type on the pressor response evoked by static contraction in rabbits. In: Journal of Applied Physiology. 1995 ; Vol. 79, No. 5. pp. 1744-1752.
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