Effect of systemically administered nitric oxide donor, sodium nitroprusside on picrotoxin-induced convulsions in rats

K. Rajasekaran, P. Leema Reddy, V. Paul

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Nitric oxide (NO), the gaseous neurotransmitter has been reported to have an endogenous anticonvulsant property. This has prompted proposals to develop NO donors as anticonvulsant drugs. In the present study, the effect of NO donor, sodium nitroprusside (SNP) on picrotoxin (PCT)-induced convulsions was investigated. A convulsant dose of PCT (5 mg/kg) was administered 5, 10, 15 and 30 rain after intraperitoneal injection of graded doses (0.7, 1.25 and 2.5 mg/kg) of SNP. SNP at doses 0.7 and 1.25 mg/kg increased dose dependently the severity of PCT-induced convulsions. But, pretreatment with the higher dose (2.5 mg/kg) of SNP was protective against PCT-induced convulsions. However, post treatment (5 and 10 min) with the same dose exacerbated convulsions and caused death of the animals. These results indicate that the vasodilator effect of SNP and an increased perfusion of PCT into brain may be responsible for the proconvulsant action of SNP. A decreased entry of PCT because of marked vasodilation and hypotension has been speculated for an inhibition of convulsions in animals pretreated with a higher dose of SNP. In conclusion, the results reveal the non-suitability of SNP to be developed as an anticonvulsant.

Original languageEnglish (US)
Pages (from-to)95-100
Number of pages6
JournalIndian Journal of Physiology and Pharmacology
Volume45
Issue number1
StatePublished - Jan 16 2001

Keywords

  • Convulsions
  • Nitric oxide
  • Sodium nitroprusside

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Effect of systemically administered nitric oxide donor, sodium nitroprusside on picrotoxin-induced convulsions in rats'. Together they form a unique fingerprint.

  • Cite this