Effect of T cell-derived lymphokines containing B cell differentiation factor(s) for IgG (BCDFγ) on γ-specific mRNA in murine B cells

S. Jones, Y. W. Chen, P. Isakson, J. Layton, E. Pure, C. Word, P. H. Krammer, P. Tucker, E. S. Vitetta

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29 Scopus citations

Abstract

Cytoplasmic RNA was isolated from cells cultured with LPS and LPS plus a T cell-derived supernatant (SN) (PK 7.1) containing B cell differentiation factors. The steady state levels of isotype-specific mRNA were assessed by Northern blot analysis with γ-specific C(H)3 probes. It was demonstrated that the SN induces an increase in the level of mRNA for γ1 and a concomitant decrease in the levels of mRNA for γ2b and γ3.

Original languageEnglish (US)
Pages (from-to)3049-3051
Number of pages3
JournalJournal of Immunology
Volume131
Issue number6
StatePublished - 1983

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Jones, S., Chen, Y. W., Isakson, P., Layton, J., Pure, E., Word, C., Krammer, P. H., Tucker, P., & Vitetta, E. S. (1983). Effect of T cell-derived lymphokines containing B cell differentiation factor(s) for IgG (BCDFγ) on γ-specific mRNA in murine B cells. Journal of Immunology, 131(6), 3049-3051.