Effect of T cell-derived lymphokines containing B cell differentiation factor(s) for IgG (BCDFγ) on γ-specific mRNA in murine B cells

S. Jones, Y. W. Chen, P. Isakson, J. Layton, E. Pure, C. Word, P. H. Krammer, P. Tucker, E. S. Vitetta

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Cytoplasmic RNA was isolated from cells cultured with LPS and LPS plus a T cell-derived supernatant (SN) (PK 7.1) containing B cell differentiation factors. The steady state levels of isotype-specific mRNA were assessed by Northern blot analysis with γ-specific C(H)3 probes. It was demonstrated that the SN induces an increase in the level of mRNA for γ1 and a concomitant decrease in the levels of mRNA for γ2b and γ3.

Original languageEnglish (US)
Pages (from-to)3049-3051
Number of pages3
JournalJournal of Immunology
Volume131
Issue number6
StatePublished - 1983

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Lymphokines
Interleukin-6
B-Lymphocytes
Immunoglobulin G
T-Lymphocytes
Messenger RNA
Northern Blotting
Cultured Cells
RNA

ASJC Scopus subject areas

  • Immunology

Cite this

Effect of T cell-derived lymphokines containing B cell differentiation factor(s) for IgG (BCDFγ) on γ-specific mRNA in murine B cells. / Jones, S.; Chen, Y. W.; Isakson, P.; Layton, J.; Pure, E.; Word, C.; Krammer, P. H.; Tucker, P.; Vitetta, E. S.

In: Journal of Immunology, Vol. 131, No. 6, 1983, p. 3049-3051.

Research output: Contribution to journalArticle

Jones, S, Chen, YW, Isakson, P, Layton, J, Pure, E, Word, C, Krammer, PH, Tucker, P & Vitetta, ES 1983, 'Effect of T cell-derived lymphokines containing B cell differentiation factor(s) for IgG (BCDFγ) on γ-specific mRNA in murine B cells', Journal of Immunology, vol. 131, no. 6, pp. 3049-3051.
Jones, S. ; Chen, Y. W. ; Isakson, P. ; Layton, J. ; Pure, E. ; Word, C. ; Krammer, P. H. ; Tucker, P. ; Vitetta, E. S. / Effect of T cell-derived lymphokines containing B cell differentiation factor(s) for IgG (BCDFγ) on γ-specific mRNA in murine B cells. In: Journal of Immunology. 1983 ; Vol. 131, No. 6. pp. 3049-3051.
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AU - Isakson, P.

AU - Layton, J.

AU - Pure, E.

AU - Word, C.

AU - Krammer, P. H.

AU - Tucker, P.

AU - Vitetta, E. S.

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