Effect of thermal stress on Frank-Starling relations in humans

T. E. Wilson, R. M. Brothers, C. Tollund, E. A. Dawson, P. Nissen, C. C. Yoshiga, C. Jons, N. H. Secher, Craig G. Crandall

Research output: Contribution to journalArticle

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Abstract

The Frank-Starling 'law of the heart' is implicated in certain types of orthostatic intolerance in humans. Environmental conditions have the capacity to modulate orthostatic tolerance, where heat stress decreases and cooling increases orthostatic tolerance. The objective of this project was to test the hypothesis that heat stress augments and cooling attenuates orthostatic-induced decreases in stroke volume (SV) via altering the operating position on a Frank-Starling curve. Pulmonary artery catheters were placed in 11 subjects for measures of pulmonary capillary wedge pressure (PCWP) and SV (thermodilution derived cardiac output/heart rate). Subjects experienced lower-body negative-pressure (LBNP) of 0, 15 and 30 mmHg during normothermia, skin-surface cooling (decrease in mean skin temperature of 4.3 ± 0.4°C (mean ± s.e.m.) via perfusing 16°C water through a tubed-lined suit), and whole-body heating (increase in blood temperature of 1.0 ± 0.1°C via perfusing 46°C water through the suit). SV was 123 ± 8, 121 ± 10, 131 ± 7 ml prior to LBNP, during normothermia, skin-surface cooling, and whole-body heating, respectfully (P = 0.20). LBNP of 30 mmHg induced greater decreases in SV during heating (-48.7 ± 6.7 ml) compared to normothermia (-33.2 ± 7.4 ml) and to cooling (-10.3 ± 2.9 ml; all P < 0.05). Relating PCWP to SV indicated that cooling values were located on the flatter portion of a Frank-Starling curve because of attenuated decreases in SV per decrease in PCWP. In contrast, heating values were located on the steeper portion of a Frank-Starling curve because of augmented decreases in SV per decrease in PCWP. These data suggest that a Frank-Starling mechanism may contribute to improvements in orthostatic tolerance during cold stress and orthostatic intolerance during heat stress.

Original languageEnglish (US)
Pages (from-to)3383-3392
Number of pages10
JournalJournal of Physiology
Volume587
Issue number13
DOIs
StatePublished - 2009

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Starlings
Stroke Volume
Hot Temperature
Pulmonary Wedge Pressure
Lower Body Negative Pressure
Heating
Orthostatic Intolerance
Thermodilution
Skin
Skin Temperature
Water
Cardiac Output
Pulmonary Artery
Catheters
Heart Rate
Temperature

ASJC Scopus subject areas

  • Physiology

Cite this

Wilson, T. E., Brothers, R. M., Tollund, C., Dawson, E. A., Nissen, P., Yoshiga, C. C., ... Crandall, C. G. (2009). Effect of thermal stress on Frank-Starling relations in humans. Journal of Physiology, 587(13), 3383-3392. https://doi.org/10.1113/jphysiol.2009.170381

Effect of thermal stress on Frank-Starling relations in humans. / Wilson, T. E.; Brothers, R. M.; Tollund, C.; Dawson, E. A.; Nissen, P.; Yoshiga, C. C.; Jons, C.; Secher, N. H.; Crandall, Craig G.

In: Journal of Physiology, Vol. 587, No. 13, 2009, p. 3383-3392.

Research output: Contribution to journalArticle

Wilson, TE, Brothers, RM, Tollund, C, Dawson, EA, Nissen, P, Yoshiga, CC, Jons, C, Secher, NH & Crandall, CG 2009, 'Effect of thermal stress on Frank-Starling relations in humans', Journal of Physiology, vol. 587, no. 13, pp. 3383-3392. https://doi.org/10.1113/jphysiol.2009.170381
Wilson TE, Brothers RM, Tollund C, Dawson EA, Nissen P, Yoshiga CC et al. Effect of thermal stress on Frank-Starling relations in humans. Journal of Physiology. 2009;587(13):3383-3392. https://doi.org/10.1113/jphysiol.2009.170381
Wilson, T. E. ; Brothers, R. M. ; Tollund, C. ; Dawson, E. A. ; Nissen, P. ; Yoshiga, C. C. ; Jons, C. ; Secher, N. H. ; Crandall, Craig G. / Effect of thermal stress on Frank-Starling relations in humans. In: Journal of Physiology. 2009 ; Vol. 587, No. 13. pp. 3383-3392.
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