Effect of two high dose vitamin D by parenteral route in treating vitamin D deficiency a prospective interventional study

Sanjay G. Gokhale, Sankalp Gokhale

Research output: Contribution to journalArticle

Abstract

Background: Vitamin D deficiency is recognized as a global public health problem. Despite ample sunshine, vitamin D deficiency is very common in the Middle East (15°–36°N) and African (35°S–37°N) countries; and in South Asian countries. Aim: To find a simple, affordable and practical plan to treat vitamin-d deficiency. Type of study: This was a prospective interventional study. Outcome variable: The primary outcome was typed as vitamin-D level more than 50 nanograms/ml as ‘yes’ and poor response or ‘no’ when it was less than 50 ng/ml. Participants: 80 Women participated in study. Laboratory tests: Vitamin D [25-OHD]-estimations were performed with LCMSMS-liquid chromatography tandem mass spectrometry. Corrective vitamin-D doses: All participants received TWO doses of Vitamin-D injections one ml at a time [600K IU/ml or 600,000 IU/ml]. All participants received their first dose; after collecting blood samples for Vitamin-D estimations. Second dose was given about a month after the first one [range 30–37 days]. These doses were given to correct the deficiency. Results: Even with this high dose treatment 60% woman had unsatisfactory Vitamin-D levels.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalJournal of Maternal-Fetal and Neonatal Medicine
DOIs
StateAccepted/In press - Jun 20 2017

Keywords

  • Genetic factors-VDBP
  • high hydroxylase enzyme activity
  • mega dose parenteral therapy
  • treatment of vitamin D deficiency
  • variable responses

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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