Effect of unilateral perinatal hypoxic-ischemic brain damage on the gross development of opposite cerebral hemisphere

J. Towfighi, C. Housman, R. C. Vannucci, D. F. Heitjan

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

The effect of unilateral perinatal cerebral hypoxic-ischemic damage on the gross development of the opposite hemisphere was investigated in immature rats. Eight-day-old rats underwent unilateral common carotid artery ligation followed by exposure to hypoxia (8% oxygen) ranging from 1 to 2 h at 37°C. The animals were sacrificed 3 weeks later, and brain damage was assessed histologically, by weighing the cerebral hemispheres, and by measuring hemispheric cross-sectional area and diameter as well as the thickness of neocortex. There were no significant differences in either the size or cortical thickness of the cerebral hemisphere contralateral to the damaged hemisphere compared to those of controls. The results are comparable to the effect of unilateral perinatal hemispheric decortication and hemispherectomy on the growth of the contralateral hemisphere and suggest that: (1) perinatal damage to one cerebral hemisphere does not significantly alter the size of the other hemisphere, and (2) the contralateral hemisphere may be used as a 'normal' reference in evaluating the extent of atrophy or infarction of a cerebral hemisphere damaged earlier by perinatal hypoxia-ischemia.

Original languageEnglish (US)
Pages (from-to)108-118
Number of pages11
JournalBiology of the Neonate
Volume65
Issue number2
DOIs
StatePublished - Jan 1 1994

Keywords

  • Brain development
  • Cerebral hemisphere
  • Hypoxic ischemia
  • Immature rat

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Biology

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