Effect of ursodeoxycholate and its taurine conjugate on bile acid synthesis and cholesterol absorption

William G M Hardison, Scott M Grundy

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Six male subjects with normal gastroenterologic function were studied to determine the effects of ursodeoxycholic (15 mg/kg · day) and tauroursodeoxycholic (20 mg/kg · day) acid feeding on bile acid synthesis and cholesterol absorption. Each bile acid was fed for 1 mo and withheld for the next month. Subjects remained on a metabolic ward and consumed a constant diet of 500 mg of cholesterol mixed with solid and liquid formulas. Before the study started, each subject received 50 μCi of [4-14C]cholesterol intravenously. During the study, stools were collected for the determination of 24-h fecal acidic and neutral sterol excretion, and blood was drawn twice weekly for determination of serum cholesterol specific activity. At the end of each month an intestinal perfusion study was performed to measure total bile acid pool size and hourly biliary secretion rates of cholesterol, phospholipid, and bile acid. From these data, the percentage of cholesterol absorption and total endogenous bile acid synthesis could be calculated. Neither ursodeoxycholic nor tauroursodeoxycholic acid feeding decreased endogenous bile acid synthesis. During bile acid feeding periods, the percentage of cholesterol absorption was decreased.

Original languageEnglish (US)
Pages (from-to)130-135
Number of pages6
JournalGastroenterology
Volume87
Issue number1
StatePublished - 1984

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Bile Acids and Salts
Cholesterol
Sterols
taurine-ursodeoxycholate conjugate
Phospholipids
Perfusion
Diet
Acids
Serum

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Effect of ursodeoxycholate and its taurine conjugate on bile acid synthesis and cholesterol absorption. / Hardison, William G M; Grundy, Scott M.

In: Gastroenterology, Vol. 87, No. 1, 1984, p. 130-135.

Research output: Contribution to journalArticle

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