Effect of vitamin B-12 deficiency on the hepatic tissue concentration of acyl carnitines

William C. Burton, Eugene P. Frenkel

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Concentrations of carnitine, acetyl carnitine, propionyl carnitine, and long chain acyl carnitines have been measured in hepatic tissue of normal and vitamin B-12 deficient rats using radiolabelled butyrobetaine to label carnitine pools. Increased levels of propionyl carnitine were seen in the livers of vitamin B-12 deprived animals when compared to those from normal animals. Methylmalonyl carnitine was not detected in the B-12 deprived animals. Free carnitine levels were no different in the livers from the B-12 deprived animals than from the normal control animals.

Original languageEnglish (US)
Pages (from-to)217-223
Number of pages7
JournalBiochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
Volume398
Issue number2
DOIs
StatePublished - Aug 25 1975

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Endocrinology

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