TY - JOUR
T1 - Effect of vitamin B-12 deficiency on the hepatic tissue concentration of acyl carnitines
AU - Burton, William C.
AU - Frenkel, Eugene P.
N1 - Funding Information:
This work was supported by the Heddens-Good Foundation and the McDermott Foundation.
PY - 1975/8/25
Y1 - 1975/8/25
N2 - Concentrations of carnitine, acetyl carnitine, propionyl carnitine, and long chain acyl carnitines have been measured in hepatic tissue of normal and vitamin B-12 deficient rats using radiolabelled butyrobetaine to label carnitine pools. Increased levels of propionyl carnitine were seen in the livers of vitamin B-12 deprived animals when compared to those from normal animals. Methylmalonyl carnitine was not detected in the B-12 deprived animals. Free carnitine levels were no different in the livers from the B-12 deprived animals than from the normal control animals.
AB - Concentrations of carnitine, acetyl carnitine, propionyl carnitine, and long chain acyl carnitines have been measured in hepatic tissue of normal and vitamin B-12 deficient rats using radiolabelled butyrobetaine to label carnitine pools. Increased levels of propionyl carnitine were seen in the livers of vitamin B-12 deprived animals when compared to those from normal animals. Methylmalonyl carnitine was not detected in the B-12 deprived animals. Free carnitine levels were no different in the livers from the B-12 deprived animals than from the normal control animals.
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U2 - 10.1016/0005-2760(75)90137-X
DO - 10.1016/0005-2760(75)90137-X
M3 - Article
C2 - 1182134
AN - SCOPUS:0016788354
SN - 0005-2760
VL - 398
SP - 217
EP - 223
JO - Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
JF - Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
IS - 2
ER -