Effect of vitreous fluidity on the measurement of blood-retinal barrier permeability using contrast-enhanced MRI.

B. A. Berkowitz, C. A. Wilson, P. S. Tofts, Ronald M Peshock

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Breakdown of the blood-retinal barrier (BRB), frequently an early clinical sign in retinopathy, can be accurately determined using contrast-enhanced MRI. However, increased vitreous fluidity with age and disease may affect the accuracy of the MRI method. We compared the permeability surface area product per area of leaky retina in eyes with normal vitreous (5.42 +/- 0.48 x 10(-4) cm/min, mean +/- SEM, n = 5) to the contralateral gas-compressed vitrectomized eyes (5.41 +/- 0.54 x 10(-4) cm/min, n = 5). The effect of vitrectomy was not significant (P = 0.325) using a Wilcoxon matched pairs signed rank test on the signed differences of the PS' values.

Original languageEnglish (US)
Pages (from-to)61-66
Number of pages6
JournalMagnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine
Volume31
Issue number1
StatePublished - Jan 1994

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Blood-Retinal Barrier
Permeability
Vitrectomy
Retina
Gases

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

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abstract = "Breakdown of the blood-retinal barrier (BRB), frequently an early clinical sign in retinopathy, can be accurately determined using contrast-enhanced MRI. However, increased vitreous fluidity with age and disease may affect the accuracy of the MRI method. We compared the permeability surface area product per area of leaky retina in eyes with normal vitreous (5.42 +/- 0.48 x 10(-4) cm/min, mean +/- SEM, n = 5) to the contralateral gas-compressed vitrectomized eyes (5.41 +/- 0.54 x 10(-4) cm/min, n = 5). The effect of vitrectomy was not significant (P = 0.325) using a Wilcoxon matched pairs signed rank test on the signed differences of the PS' values.",
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