Effect of vitreous fluidity on the measurement of blood‐retinal barrier permeability using contrast‐enhanced MRI

B. A. Berkowitz, C. A. Wilson, P. S. Tofts, Ronald M Peshock

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Breakdown of the blood‐retinal barrier (BRB), frequently an early clinical sign in retinopathy, can be accurately determined using contrast‐enhanced MRI. However, increased vitreous fluidity with age and disease may affect the accuracy of the MRI method. We compared the permeability surface area product per area of leaky retina in eyes with normal vitreous (5.42 ± 0.48 × 10−4 cm/min, mean ± SEM, n = 5) to the contralateral gas‐compressed vitrectomized eyes (5.41 ± 0.54 × 10−4 cm/min, n = 5). The effect of vitrectomy was not significant (P = 0.325) using a Wilcoxon matched pairs signed rank test on the signed differences of the PS' values.

Original languageEnglish (US)
Pages (from-to)61-66
Number of pages6
JournalMagnetic resonance in medicine
Volume31
Issue number1
DOIs
StatePublished - Jan 1994

Keywords

  • Gd‐DTPA
  • MRI
  • blood‐retinal barrier
  • permeability

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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