Effective Pharmacotherapy of Alcoholic Amnestic Disorder with Fluvoxamine: Preliminary Findings

P. R. Martin, B. Adinoff, M. J. Eckardt, J. M. Stapleton, G. A H Bone, D. R. Rubinow, E. A. Lane, M. Linnoila

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

Ten patients with alcoholic chronic organic brain disease were categorized as having alcohol amnestic disorder, or Korsakoff's psychosis (n = 6), dementia associated with alcoholism (n = 3), or compensated alcoholic liver disease (n =1). All patients had severe deficits in memory for recently acquired information (episodic memory). Patients with alcohol dementia also showed global intellectual decline, including decreased performance on measures of semantic (knowledge) memory and reduction in levels of cerebrospinal fluid somatostatin. In a 4-week double-blind crossover design, the serotonin-uptake blocker fluvoxamine maleate (100 to 200 mg/d) was found to improve episodic memory in only the patients with alcohol amnestic disorder. These improvements in memory were significantly correlated with reductions in levels of cerebrospinal fluid 5-hydroxyindoleacetic acid, suggesting that facilitation of serotonergic neurotransmission may ameliorate the episodic memory failure in patients with alcohol amnestic disorder.

Original languageEnglish (US)
Pages (from-to)617-621
Number of pages5
JournalArchives of General Psychiatry
Volume46
Issue number7
DOIs
StatePublished - Jul 1989

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

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    Martin, P. R., Adinoff, B., Eckardt, M. J., Stapleton, J. M., Bone, G. A. H., Rubinow, D. R., Lane, E. A., & Linnoila, M. (1989). Effective Pharmacotherapy of Alcoholic Amnestic Disorder with Fluvoxamine: Preliminary Findings. Archives of General Psychiatry, 46(7), 617-621. https://doi.org/10.1001/archpsyc.1989.01810070043008