Effectiveness of local cooling for enhancing tissue ischemia tolerance in people with spinal cord injury

Yi Ting Tzen, David M. Brienza, Patricia E. Karg, Patrick J. Loughlin

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Objective: To investigate the effects of localized cooling and cooling rate on pressure-induced ischemia for people with and without neurological deficits. Design: A 2× 3 mixed factorial design with two groups: (1) people with spinal cord injury (SCI) and (2) people without neurological deficits (control), and three test conditions: (1) pressure only, (2) pressure with fast cooling (-4°C/min), and (3) pressure with slow cooling (-0.33°C/min). Setting: University laboratory. Participants: Fourteen controls and 14 individuals with SCI. Interventions: Pressure on the sacrum was 0.4 kPa for 5 minutes, then 8 kPa for 20 minutes, and finally 0.4 kPa for 15 minutes. Fast and slow cooling to 25°C applied during 8 kPa of pressure. Outcome measures: Reactive hyperemia and its spectral densities in the metabolic, neurogenic, and myogenic frequency ranges. Results: In controls, reactive hyperemia was greater in pressure only as compared with both cooling conditions. No change was noted in all spectral densities in both cooling conditions, and only neurogenic spectral density increased without cooling. In subjects with SCI, no difference was noted in reactive hyperemia among conditions. However, metabolic and myogenic spectral densities increased without cooling and all spectral densities increased with slow cooling. No change was noted in all spectral densities with fast cooling. Conclusion: Local cooling reduced the severity of ischemia in controls. This protective effect may be masked in subjects with SCI due to chronic microvascular changes; however, spectral analysis suggested local cooling may reduce metabolic vasodilation. These findings provide evidence towards the development of support surfaces with temperature control for weight-bearing soft tissues.

Original languageEnglish (US)
Pages (from-to)357-364
Number of pages8
JournalJournal of Spinal Cord Medicine
Volume36
Issue number4
DOIs
StatePublished - Jul 2013
Externally publishedYes

Keywords

  • Induced hypothermia
  • Ischemia
  • Laser-Doppler flowmetry
  • Pressure ulcer
  • Reactive hyperemia
  • Skin temperature
  • Spinal cord injuries

ASJC Scopus subject areas

  • Clinical Neurology

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