Effects of α-adrenergic blockade on cardiovascular responses to static exercise in cats

T. G. Waldrop, M. Bielecki, W. J. Gonyea, J. H. Mitchell

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Abstract

Static exercise performed by conscious cats elicits increases in heart rate (HR), left ventricular systolic pressure (LVSP), and the maximal rate of left ventricular pressure development [LV(dP/dt)(max)]. The increased HR is mediated primarily by withdrawal of parasympathetic tone, whereas a β-adrenergic mechanism is responsible for the LV(dP/dt)(max) increase. In the present study the cardiovascular responses to static exercise in awake cats was recorded before and after α-adrenergic blockade. Pressure transducers were implanted into the left ventricle of cats who had been trained operantly to perform static exercise. Significant increases in LVSP, LV(dP/dt)(max) and HR occurred in all cats during static exercise before blockade. In contrast, α-adrenergic blockade (phentolamine, 2.5 mg/kg iv) abolished the exercise-induced increase in LVSP but did not prevent increases in HR and LV(dP/dt)(max). The cats performed fewer exercise bouts per day during α-blockade than when unblocked. We conclude that an α-adrenergic mechanism mediates the increase in LVSP in response to static exercise in conscious cats.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume250
Issue number1
StatePublished - 1986

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Adrenergic Agents
Ventricular Pressure
Cats
Heart Rate
Blood Pressure
Pressure Transducers
Phentolamine
Heart Ventricles

ASJC Scopus subject areas

  • Physiology

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Effects of α-adrenergic blockade on cardiovascular responses to static exercise in cats. / Waldrop, T. G.; Bielecki, M.; Gonyea, W. J.; Mitchell, J. H.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 250, No. 1, 1986.

Research output: Contribution to journalArticle

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