Effects of γ-aminobutyric acid on insulin, glucagon, and somatostatin release from isolated perfused dog pancreas

K. Kawai, Roger H Unger

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The effects of γ-aminobutyric acid (GABA) on the secretion of insulin, glucagon, and somatostatin were studied in the isolated dog pancreas. Insulin secretion was inhibited in a dose-related fashion for 10 min or more by as little as 1 μM GABA. A prompt but small and transitory rise in somatostatin secretion, lasting only 1 min, occurred at GABA concentrations of 10 and 100 μM, levels that exert inhibitory effects on nervous tissue. Bicuculline, a GABA antagonist, inhibited insulin secretion and did not antagonize GABA-mediated insulin inhibition. The results suggest that GABA in concentrations that are known to exist in islet tissue can influence the secretion of islet hormones.

Original languageEnglish (US)
Pages (from-to)111-113
Number of pages3
JournalEndocrinology
Volume113
Issue number1
StatePublished - 1983

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Aminobutyrates
Somatostatin
Glucagon
gamma-Aminobutyric Acid
Pancreas
Dogs
Insulin
GABA Antagonists
Nerve Tissue
Bicuculline
Hormones

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Effects of γ-aminobutyric acid on insulin, glucagon, and somatostatin release from isolated perfused dog pancreas. / Kawai, K.; Unger, Roger H.

In: Endocrinology, Vol. 113, No. 1, 1983, p. 111-113.

Research output: Contribution to journalArticle

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