TY - JOUR
T1 - Effects of a large supper on glucose levels the following morning in patients with type 2 diabetes
AU - Arauz-Pacheco, Carlos
AU - Clements, Gigi
AU - Cercone, Susan
AU - Brinkley, Linda
AU - Raskin, Philip
PY - 1998
Y1 - 1998
N2 - Seventeen patients were studied to test the hypothesis that a large evening meal influences the fasting glucose level and glucose tolerance the following morning in patients with type 2 diabetes. Oral hypoglycemic agents were discontinued for 2 weeks. The baseline fasting plasma glucose levels were 12.3 ± 0.9 mmol/L. Fasting and postprandial (post-Sustacal) glucose, insulin, and C-peptide measurements were performed the morning after the patients received three separate meal protocols spaced 1 week apart. The caloric distribution of the meal protocols was (1) 7 kcal/kg of ideal body weight breakfast and lunch and 14 kcal/kg supper (small supper); (2) 7 kcal/kg breakfast and lunch and 28 kcal/kg for supper (large supper); and (3) 14 kcal/kg breakfast and lunch (no supper). Fasting glucose levels were higher the morning after the large supper compared to no supper (13.6 ± 0.7 versus 12.3 ± 0.5 mmol/L, p < 0.05) and also to the small supper (13.6 ± 0.7 versus 12.5 ± 0..6 mmol/L, p = 0.05). No difference was observed in the fasting glucose levels behueen the small supper and no supper (p > 0.2). The fasting insulin and C-peptide levels, and the post-Sustacal areas under the curve of glucose, insulin, and C-peptide did not differ among the meals. In patients with type 2 diabetes, a large evening meal is associated with a modest elevation in fasting glucose the following morning.
AB - Seventeen patients were studied to test the hypothesis that a large evening meal influences the fasting glucose level and glucose tolerance the following morning in patients with type 2 diabetes. Oral hypoglycemic agents were discontinued for 2 weeks. The baseline fasting plasma glucose levels were 12.3 ± 0.9 mmol/L. Fasting and postprandial (post-Sustacal) glucose, insulin, and C-peptide measurements were performed the morning after the patients received three separate meal protocols spaced 1 week apart. The caloric distribution of the meal protocols was (1) 7 kcal/kg of ideal body weight breakfast and lunch and 14 kcal/kg supper (small supper); (2) 7 kcal/kg breakfast and lunch and 28 kcal/kg for supper (large supper); and (3) 14 kcal/kg breakfast and lunch (no supper). Fasting glucose levels were higher the morning after the large supper compared to no supper (13.6 ± 0.7 versus 12.3 ± 0.5 mmol/L, p < 0.05) and also to the small supper (13.6 ± 0.7 versus 12.5 ± 0..6 mmol/L, p = 0.05). No difference was observed in the fasting glucose levels behueen the small supper and no supper (p > 0.2). The fasting insulin and C-peptide levels, and the post-Sustacal areas under the curve of glucose, insulin, and C-peptide did not differ among the meals. In patients with type 2 diabetes, a large evening meal is associated with a modest elevation in fasting glucose the following morning.
UR - http://www.scopus.com/inward/record.url?scp=0031980002&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031980002&partnerID=8YFLogxK
U2 - 10.1016/S1056-8727(97)00073-1
DO - 10.1016/S1056-8727(97)00073-1
M3 - Article
C2 - 9559482
AN - SCOPUS:0031980002
SN - 1056-8727
VL - 12
SP - 61
EP - 64
JO - Journal of Diabetes and Its Complications
JF - Journal of Diabetes and Its Complications
IS - 2
ER -