Effects of a large supper on glucose levels the following morning in patients with type 2 diabetes

Carlos Arauz-Pacheco, Gigi Clements, Susan Cercone, Linda Brinkley, Philip Raskin

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Seventeen patients were studied to test the hypothesis that a large evening meal influences the fasting glucose level and glucose tolerance the following morning in patients with type 2 diabetes. Oral hypoglycemic agents were discontinued for 2 weeks. The baseline fasting plasma glucose levels were 12.3 ± 0.9 mmol/L. Fasting and postprandial (post-Sustacal) glucose, insulin, and C-peptide measurements were performed the morning after the patients received three separate meal protocols spaced 1 week apart. The caloric distribution of the meal protocols was (1) 7 kcal/kg of ideal body weight breakfast and lunch and 14 kcal/kg supper (small supper); (2) 7 kcal/kg breakfast and lunch and 28 kcal/kg for supper (large supper); and (3) 14 kcal/kg breakfast and lunch (no supper). Fasting glucose levels were higher the morning after the large supper compared to no supper (13.6 ± 0.7 versus 12.3 ± 0.5 mmol/L, p < 0.05) and also to the small supper (13.6 ± 0.7 versus 12.5 ± 0..6 mmol/L, p = 0.05). No difference was observed in the fasting glucose levels behueen the small supper and no supper (p > 0.2). The fasting insulin and C-peptide levels, and the post-Sustacal areas under the curve of glucose, insulin, and C-peptide did not differ among the meals. In patients with type 2 diabetes, a large evening meal is associated with a modest elevation in fasting glucose the following morning.

Original languageEnglish (US)
Pages (from-to)61-64
Number of pages4
JournalJournal of Diabetes and Its Complications
Volume12
Issue number2
DOIs
StatePublished - Jan 1 1998

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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