Effects of a rostral motor cortex lesion on primary motor cortex hand representation topography in primates

Kathleen M. Friel, Scott Barbay, Shawn B. Frost, Erik J. Plautz, Ann M. Stowe, Numa Dancause, Elena V. Zoubina, Randolph J. Nudo

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background. Small lesions to rostral versus caudal portions of the hand representation in the primary motor cortex (M1) produce different behavioral deficits. The goal of the present study was to determine if rehabilitative training has similar effects on functional topography of the spared M1 after rostral versus previously reported caudal M1 lesions. Methods. Following a lesion to the rostral M1 hand area, monkeys were trained for 1 h/day for 30 days to retrieve food pellets from small wells using their impaired hand. Electrophysiological maps of the M1 were derived in anesthetized monkeys before infarct and after rehabilitative training using intracortical microstimulation. Results. After a lesion to the rostral M1 and rehabilitative training, the size of the spared hand representation decreased 1.2%. This change is not statistically different from the 9% increase seen after caudal M1 lesion and rehabilitative training (P > 0.2). Conclusion. Postlesion training spares peri-infarct hand area regardless of whether the lesion is in the rostral or caudal M1.

Original languageEnglish (US)
Pages (from-to)51-61
Number of pages11
JournalNeurorehabilitation and Neural Repair
Volume21
Issue number1
DOIs
StatePublished - Mar 2007

Fingerprint

Motor Cortex
Primates
Hand
Haplorhini
Food

Keywords

  • Cortical plasticity
  • Recovery
  • Rehabilitation
  • Stroke

ASJC Scopus subject areas

  • Rehabilitation
  • Clinical Neurology
  • Neuroscience(all)
  • Health Professions(all)

Cite this

Friel, K. M., Barbay, S., Frost, S. B., Plautz, E. J., Stowe, A. M., Dancause, N., ... Nudo, R. J. (2007). Effects of a rostral motor cortex lesion on primary motor cortex hand representation topography in primates. Neurorehabilitation and Neural Repair, 21(1), 51-61. https://doi.org/10.1177/1545968306291851

Effects of a rostral motor cortex lesion on primary motor cortex hand representation topography in primates. / Friel, Kathleen M.; Barbay, Scott; Frost, Shawn B.; Plautz, Erik J.; Stowe, Ann M.; Dancause, Numa; Zoubina, Elena V.; Nudo, Randolph J.

In: Neurorehabilitation and Neural Repair, Vol. 21, No. 1, 03.2007, p. 51-61.

Research output: Contribution to journalArticle

Friel, KM, Barbay, S, Frost, SB, Plautz, EJ, Stowe, AM, Dancause, N, Zoubina, EV & Nudo, RJ 2007, 'Effects of a rostral motor cortex lesion on primary motor cortex hand representation topography in primates', Neurorehabilitation and Neural Repair, vol. 21, no. 1, pp. 51-61. https://doi.org/10.1177/1545968306291851
Friel, Kathleen M. ; Barbay, Scott ; Frost, Shawn B. ; Plautz, Erik J. ; Stowe, Ann M. ; Dancause, Numa ; Zoubina, Elena V. ; Nudo, Randolph J. / Effects of a rostral motor cortex lesion on primary motor cortex hand representation topography in primates. In: Neurorehabilitation and Neural Repair. 2007 ; Vol. 21, No. 1. pp. 51-61.
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