Effects of age and aerobic fitness on myocardial lipid content

Satyam Sarma, Graeme Carrick-Ranson, Naoki Fujimoto, Beverley Adams-Huet, Paul S. Bhella, Jeffrey L. Hastings, Keri M. Shafer, Shigeki Shibata, Kara Boyd, Dean Palmer, Edward W. Szczepaniak, Lidia S. Szczepaniak, Benjamin D. Levine

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background-Aging and sedentary lifestyles lead to cardiac atrophy, ventricular stiffening, and impaired diastolic function. Both conditions are marked by increased adiposity, which can lead to ectopic fat deposition in nonadipocyte tissues including the myocardium. The effect of excess intramyocardial fat on cardiac function in nonobese individuals is unknown. Methods and Results-Cardiac lipid content was measured by magnetic resonance spectroscopy in 153 healthy nonobese subjects with varying fitness levels quantified by peak oxygen uptake during treadmill exercise. Cardiac function (echo) and left ventricular (LV) filling pressures (right heart catheterization) were measured under varying preloads. LV stiffness was calculated from a curve fit of the diastolic portion of the pressure-volume curve. The strongest clinical predictors of lipid content were body mass index (β=+0.03; 95% confidence interval, 0.001-0.06) and peak oxygen uptake (β=-0.02; 95% confidence interval, -0.03 to -0.009; R2=0.14; P<0.001). Subjects in the highest quintile had smaller LV end-diastolic volumes (68±13 versus 58±12 mL/m2; P<0.01) and decreased peak early mitral annular and increased peak late mitral inflow velocities. There were no differences in LV stiffness, but a leftward shift in the pressure-volume curve suggested a less distensible ventricle with increasing myocardial lipid levels. After adjusting for age, fitness, and body mass index, echocardiographic and morphometric differences among groups were attenuated and no longer significant. Conclusions-Body mass index and fitness levels are the strongest predictors of myocardial lipid content in nonobese humans. Cardiac lipid content is associated with decreased ventricular distensibility, and it may provide a causal mechanism linking changes in LV function related to age and fitness.

Original languageEnglish (US)
Pages (from-to)1048-1055
Number of pages8
JournalCirculation: Cardiovascular Imaging
Volume6
Issue number6
DOIs
StatePublished - Nov 2013

Fingerprint

Lipids
Body Mass Index
Fats
Confidence Intervals
Oxygen
Sedentary Lifestyle
Adiposity
Ventricular Pressure
Cardiac Catheterization
Left Ventricular Function
Stroke Volume
Atrophy
Myocardium
Healthy Volunteers
Magnetic Resonance Spectroscopy
Exercise
Blood Pressure
Pressure

Keywords

  • Aging
  • Exercise
  • Ventricular remodeling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Effects of age and aerobic fitness on myocardial lipid content. / Sarma, Satyam; Carrick-Ranson, Graeme; Fujimoto, Naoki; Adams-Huet, Beverley; Bhella, Paul S.; Hastings, Jeffrey L.; Shafer, Keri M.; Shibata, Shigeki; Boyd, Kara; Palmer, Dean; Szczepaniak, Edward W.; Szczepaniak, Lidia S.; Levine, Benjamin D.

In: Circulation: Cardiovascular Imaging, Vol. 6, No. 6, 11.2013, p. 1048-1055.

Research output: Contribution to journalArticle

Sarma, S, Carrick-Ranson, G, Fujimoto, N, Adams-Huet, B, Bhella, PS, Hastings, JL, Shafer, KM, Shibata, S, Boyd, K, Palmer, D, Szczepaniak, EW, Szczepaniak, LS & Levine, BD 2013, 'Effects of age and aerobic fitness on myocardial lipid content', Circulation: Cardiovascular Imaging, vol. 6, no. 6, pp. 1048-1055. https://doi.org/10.1161/CIRCIMAGING.113.000565
Sarma, Satyam ; Carrick-Ranson, Graeme ; Fujimoto, Naoki ; Adams-Huet, Beverley ; Bhella, Paul S. ; Hastings, Jeffrey L. ; Shafer, Keri M. ; Shibata, Shigeki ; Boyd, Kara ; Palmer, Dean ; Szczepaniak, Edward W. ; Szczepaniak, Lidia S. ; Levine, Benjamin D. / Effects of age and aerobic fitness on myocardial lipid content. In: Circulation: Cardiovascular Imaging. 2013 ; Vol. 6, No. 6. pp. 1048-1055.
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abstract = "Background-Aging and sedentary lifestyles lead to cardiac atrophy, ventricular stiffening, and impaired diastolic function. Both conditions are marked by increased adiposity, which can lead to ectopic fat deposition in nonadipocyte tissues including the myocardium. The effect of excess intramyocardial fat on cardiac function in nonobese individuals is unknown. Methods and Results-Cardiac lipid content was measured by magnetic resonance spectroscopy in 153 healthy nonobese subjects with varying fitness levels quantified by peak oxygen uptake during treadmill exercise. Cardiac function (echo) and left ventricular (LV) filling pressures (right heart catheterization) were measured under varying preloads. LV stiffness was calculated from a curve fit of the diastolic portion of the pressure-volume curve. The strongest clinical predictors of lipid content were body mass index (β=+0.03; 95{\%} confidence interval, 0.001-0.06) and peak oxygen uptake (β=-0.02; 95{\%} confidence interval, -0.03 to -0.009; R2=0.14; P<0.001). Subjects in the highest quintile had smaller LV end-diastolic volumes (68±13 versus 58±12 mL/m2; P<0.01) and decreased peak early mitral annular and increased peak late mitral inflow velocities. There were no differences in LV stiffness, but a leftward shift in the pressure-volume curve suggested a less distensible ventricle with increasing myocardial lipid levels. After adjusting for age, fitness, and body mass index, echocardiographic and morphometric differences among groups were attenuated and no longer significant. Conclusions-Body mass index and fitness levels are the strongest predictors of myocardial lipid content in nonobese humans. Cardiac lipid content is associated with decreased ventricular distensibility, and it may provide a causal mechanism linking changes in LV function related to age and fitness.",
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AU - Carrick-Ranson, Graeme

AU - Fujimoto, Naoki

AU - Adams-Huet, Beverley

AU - Bhella, Paul S.

AU - Hastings, Jeffrey L.

AU - Shafer, Keri M.

AU - Shibata, Shigeki

AU - Boyd, Kara

AU - Palmer, Dean

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AU - Levine, Benjamin D.

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N2 - Background-Aging and sedentary lifestyles lead to cardiac atrophy, ventricular stiffening, and impaired diastolic function. Both conditions are marked by increased adiposity, which can lead to ectopic fat deposition in nonadipocyte tissues including the myocardium. The effect of excess intramyocardial fat on cardiac function in nonobese individuals is unknown. Methods and Results-Cardiac lipid content was measured by magnetic resonance spectroscopy in 153 healthy nonobese subjects with varying fitness levels quantified by peak oxygen uptake during treadmill exercise. Cardiac function (echo) and left ventricular (LV) filling pressures (right heart catheterization) were measured under varying preloads. LV stiffness was calculated from a curve fit of the diastolic portion of the pressure-volume curve. The strongest clinical predictors of lipid content were body mass index (β=+0.03; 95% confidence interval, 0.001-0.06) and peak oxygen uptake (β=-0.02; 95% confidence interval, -0.03 to -0.009; R2=0.14; P<0.001). Subjects in the highest quintile had smaller LV end-diastolic volumes (68±13 versus 58±12 mL/m2; P<0.01) and decreased peak early mitral annular and increased peak late mitral inflow velocities. There were no differences in LV stiffness, but a leftward shift in the pressure-volume curve suggested a less distensible ventricle with increasing myocardial lipid levels. After adjusting for age, fitness, and body mass index, echocardiographic and morphometric differences among groups were attenuated and no longer significant. Conclusions-Body mass index and fitness levels are the strongest predictors of myocardial lipid content in nonobese humans. Cardiac lipid content is associated with decreased ventricular distensibility, and it may provide a causal mechanism linking changes in LV function related to age and fitness.

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