TY - JOUR
T1 - Effects of age on circadian rhythms are similar in wild-type and heterozygous Clock mutant mice
AU - Kolker, Daniel E.
AU - Vitaterna, Martha Hotz
AU - Fruechte, Ethan M.
AU - Takahashi, Joseph S.
AU - Turek, Fred W.
N1 - Funding Information:
This work was supported by Grants R01-AG-18200 (to F.W.T.) and P01-AG-11412 (to F.W.T. and J.S.T.) from the National Institutes of Health. J.S.T. is an investigator in the Howard Hughes Medical Institute.
PY - 2004/4
Y1 - 2004/4
N2 - The amplitudes of many circadian rhythms, at the behavioral, physiological, cellular, and biochemical levels, decrease with advanced age. Previous studies suggest that the amplitude of the central circadian pacemaker is decreased in old animals. Recently, it has been reported that expression of several circadian clock genes, including Clock, is lower in the master circadian pacemaker of old rodents. To test the hypothesis that decreased activity of a circadian clock gene renders animals more susceptible to the effects of aging, we analyzed the circadian rhythm of locomotor activity in young and old wild-type and heterozygous Clock mutant mice. We found that the effects of age and the Clock mutation were additive. These results indicate that age-related changes in circadian rhythmicity occur equally in wild-type and heterozygous Clock mutants, suggesting that the Clock mutation does not render mice more susceptible to the effects of age on the circadian pacemaker.
AB - The amplitudes of many circadian rhythms, at the behavioral, physiological, cellular, and biochemical levels, decrease with advanced age. Previous studies suggest that the amplitude of the central circadian pacemaker is decreased in old animals. Recently, it has been reported that expression of several circadian clock genes, including Clock, is lower in the master circadian pacemaker of old rodents. To test the hypothesis that decreased activity of a circadian clock gene renders animals more susceptible to the effects of aging, we analyzed the circadian rhythm of locomotor activity in young and old wild-type and heterozygous Clock mutant mice. We found that the effects of age and the Clock mutation were additive. These results indicate that age-related changes in circadian rhythmicity occur equally in wild-type and heterozygous Clock mutants, suggesting that the Clock mutation does not render mice more susceptible to the effects of age on the circadian pacemaker.
KW - Aging
KW - Circadian rhythm
KW - Clock
KW - Clock mutation
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U2 - 10.1016/j.neurobiolaging.2003.06.007
DO - 10.1016/j.neurobiolaging.2003.06.007
M3 - Article
C2 - 15013573
AN - SCOPUS:1542298226
SN - 0197-4580
VL - 25
SP - 517
EP - 523
JO - Neurobiology of Aging
JF - Neurobiology of Aging
IS - 4
ER -