Effects of age on circadian rhythms are similar in wild-type and heterozygous Clock mutant mice

Daniel E. Kolker, Martha Hotz Vitaterna, Ethan M. Fruechte, Joseph S. Takahashi, Fred W. Turek

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The amplitudes of many circadian rhythms, at the behavioral, physiological, cellular, and biochemical levels, decrease with advanced age. Previous studies suggest that the amplitude of the central circadian pacemaker is decreased in old animals. Recently, it has been reported that expression of several circadian clock genes, including Clock, is lower in the master circadian pacemaker of old rodents. To test the hypothesis that decreased activity of a circadian clock gene renders animals more susceptible to the effects of aging, we analyzed the circadian rhythm of locomotor activity in young and old wild-type and heterozygous Clock mutant mice. We found that the effects of age and the Clock mutation were additive. These results indicate that age-related changes in circadian rhythmicity occur equally in wild-type and heterozygous Clock mutants, suggesting that the Clock mutation does not render mice more susceptible to the effects of age on the circadian pacemaker.

Original languageEnglish (US)
Pages (from-to)517-523
Number of pages7
JournalNeurobiology of Aging
Volume25
Issue number4
DOIs
StatePublished - Apr 2004

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Circadian Clocks
Circadian Rhythm
Mutation
Periodicity
Locomotion
Genes
Rodentia

Keywords

  • Aging
  • Circadian rhythm
  • Clock
  • Clock mutation

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Effects of age on circadian rhythms are similar in wild-type and heterozygous Clock mutant mice. / Kolker, Daniel E.; Vitaterna, Martha Hotz; Fruechte, Ethan M.; Takahashi, Joseph S.; Turek, Fred W.

In: Neurobiology of Aging, Vol. 25, No. 4, 04.2004, p. 517-523.

Research output: Contribution to journalArticle

Kolker, Daniel E. ; Vitaterna, Martha Hotz ; Fruechte, Ethan M. ; Takahashi, Joseph S. ; Turek, Fred W. / Effects of age on circadian rhythms are similar in wild-type and heterozygous Clock mutant mice. In: Neurobiology of Aging. 2004 ; Vol. 25, No. 4. pp. 517-523.
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