Effects of Allergic Sensitization on Antiviral Immunity: Allergen, Virus, and Host Cell Mechanisms

Regina K. Rowe, Michelle A. Gill

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Purpose of Review: Multiple clinical and epidemiological studies demonstrate links between allergic sensitization and virus-induced atopic disease exacerbations. This review summarizes the recent findings regarding allergen, viral, and host cellular mechanisms relevant to these observations. Recent Findings: Recent studies have focused on the molecular pathways and genetic influences involved in allergen-mediated inhibition of innate antiviral immune responses. Multiple tissue and cell types from atopic individuals across the atopy spectrum exhibit deficient interferon responses to a variety of virus infections. Impairment in barrier function, viral RNA and DNA recognition by intracellular sensing molecules, and dysregulation of signaling components are broadly affected by allergic sensitization. Finally, genetic predisposition by numerous nucleotide polymorphisms also impacts immune pathways and potentially contributes to virus-associated atopic disease pathogenesis. Summary: Allergen-virus interactions in the setting of atopy involve complex tissue and cellular mechanisms. Future studies defining the pathways underlying these interactions could uncover potential therapeutic targets. Available data suggest that therapies tailored to restore specific components of antiviral responses will likely lead to improved clinical outcomes in allergic disease.

Original languageEnglish (US)
Article number9
JournalCurrent Allergy and Asthma Reports
Volume17
Issue number2
DOIs
StatePublished - Feb 1 2017

Fingerprint

Allergens
Antiviral Agents
Immunity
Viruses
Viral DNA
Viral RNA
Virus Diseases
Genetic Predisposition to Disease
Innate Immunity
Interferons
Disease Progression
Epidemiologic Studies
Molecular Biology
Nucleotides
Therapeutics
Clinical Studies

Keywords

  • Allergic asthma
  • Allergic sensitization
  • Antiviral response
  • Atopic dermatitis
  • Atopy
  • Viral infection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

Cite this

Effects of Allergic Sensitization on Antiviral Immunity : Allergen, Virus, and Host Cell Mechanisms. / Rowe, Regina K.; Gill, Michelle A.

In: Current Allergy and Asthma Reports, Vol. 17, No. 2, 9, 01.02.2017.

Research output: Contribution to journalReview article

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