Effects of altering palmitylation sites on biosynthesis and function of the influenza virus hemagglutinin

Hussein Y. Naim, Bilal Amarneh, Nicholas T. Ktistakis, Michael G. Roth

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Mutagenesis studies indicated that the three cytoplasmic cysteines of the influenza virus A/Japan/305/57 hemagglutinin (HA) are all palmitylated, but to an unequal extent. Replacement of all three cysteines abolished palmitylation, but affected neither HA biosynthesis nor function. Palmitate was not required for HA to be incorporated into virions.

Original languageEnglish (US)
Pages (from-to)7585-7588
Number of pages4
JournalJournal of Virology
Volume66
Issue number12
StatePublished - Dec 1992

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Hemagglutinins
hemagglutinins
Orthomyxoviridae
biosynthesis
Cysteine
cysteine
Palmitates
palmitates
Influenza A virus
virion
mutagenesis
Mutagenesis
Virion
Japan

ASJC Scopus subject areas

  • Immunology

Cite this

Effects of altering palmitylation sites on biosynthesis and function of the influenza virus hemagglutinin. / Naim, Hussein Y.; Amarneh, Bilal; Ktistakis, Nicholas T.; Roth, Michael G.

In: Journal of Virology, Vol. 66, No. 12, 12.1992, p. 7585-7588.

Research output: Contribution to journalArticle

Naim, Hussein Y. ; Amarneh, Bilal ; Ktistakis, Nicholas T. ; Roth, Michael G. / Effects of altering palmitylation sites on biosynthesis and function of the influenza virus hemagglutinin. In: Journal of Virology. 1992 ; Vol. 66, No. 12. pp. 7585-7588.
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