TY - JOUR
T1 - Effects of aminophylline in the conscious dog after coronary occlusion
AU - Rutherford, John D.
AU - Vatner, Stephen F.
AU - Braunwald, Eugene
N1 - Funding Information:
From the Cardiovascular Division of the Departments of Medicine, Harvard Medical School and Brigham and Women’s Hospital, Boston, Massachusetts, and the New England Regional Primate Research Center, Southboro, Massachusetts. This study was supported in part by Grants HL 17459 and HL 26215 from the U.S. Public Health Service, the National Heart, Lung, and Blood Institute, Bethesda, Maryland. Manuscript received March 19, 1961; revised manuscript received June 15, 1961, accepted June 25, 198 1. l Recipient of an Overseas Research Fellowship of the New Zealand National Heart Foutition and the Medical Research Council of New Zealand.
PY - 1981/12
Y1 - 1981/12
N2 - The effects of aminophylline were examined in 19 conscious dogs subjected to coronary arterial occlusion. Measurements were made of left ventricular pressure and its first derivative ( dP dt), segment length and the velocity of segment length shortening in normal and severely ischemic zones. Regional blood flow was measured in these zones using the radioactive microsphere technique. Coronary occlusion increased heart rate, mean arterial pressure and left ventricular end-diastolic pressure but did not change left ventricular systolic pressure or dP dt significantly. It also resulted in increased end-diastolic segment length and reduced segment length shortening (114 ± 6 percent, that is, paradoxical bulging) associated with marked reduction of blood flow to ischemic myocardium. Aminophylline, 1 mg/kg per min for 9 to 15 minutes administered after occlusion, increased heart rate 6 ± 2 beats/min, mean arterial pressure 5 ± 1 mm Hg, left ventricular systolic pressure 9 ± 2 mm Hg and left ventricular dP dt 670 ± 50 mm Hg/s while reducing left ventricular end-diastolic pressure by 3.4 ± 0.3 mm Hg. In severely ischemic zones aminophylline increased transmural blood flow by 21 ± 8.0 percent (p < 0.02), reduced end-diastolic segment length by 0.23 ± 0.05 mm (p < 0.01) and reduced paradoxical bulging by 0.15 ± 0.06 mm (p < 0.02). Thus, in the presence of coronary arterial occlusion, aminophylline increased mean arterial pressure, left ventricular dP dt and heart rate while reducing left ventricular end-diastolic pressure. In severely ischemic myocardium aminophylline appeared to exert a salutary effect and improved both regional perfusion and function.
AB - The effects of aminophylline were examined in 19 conscious dogs subjected to coronary arterial occlusion. Measurements were made of left ventricular pressure and its first derivative ( dP dt), segment length and the velocity of segment length shortening in normal and severely ischemic zones. Regional blood flow was measured in these zones using the radioactive microsphere technique. Coronary occlusion increased heart rate, mean arterial pressure and left ventricular end-diastolic pressure but did not change left ventricular systolic pressure or dP dt significantly. It also resulted in increased end-diastolic segment length and reduced segment length shortening (114 ± 6 percent, that is, paradoxical bulging) associated with marked reduction of blood flow to ischemic myocardium. Aminophylline, 1 mg/kg per min for 9 to 15 minutes administered after occlusion, increased heart rate 6 ± 2 beats/min, mean arterial pressure 5 ± 1 mm Hg, left ventricular systolic pressure 9 ± 2 mm Hg and left ventricular dP dt 670 ± 50 mm Hg/s while reducing left ventricular end-diastolic pressure by 3.4 ± 0.3 mm Hg. In severely ischemic zones aminophylline increased transmural blood flow by 21 ± 8.0 percent (p < 0.02), reduced end-diastolic segment length by 0.23 ± 0.05 mm (p < 0.01) and reduced paradoxical bulging by 0.15 ± 0.06 mm (p < 0.02). Thus, in the presence of coronary arterial occlusion, aminophylline increased mean arterial pressure, left ventricular dP dt and heart rate while reducing left ventricular end-diastolic pressure. In severely ischemic myocardium aminophylline appeared to exert a salutary effect and improved both regional perfusion and function.
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U2 - 10.1016/0002-9149(81)90322-2
DO - 10.1016/0002-9149(81)90322-2
M3 - Article
C2 - 7304457
AN - SCOPUS:0019669997
SN - 0002-9149
VL - 48
SP - 1071
EP - 1076
JO - The American journal of cardiology
JF - The American journal of cardiology
IS - 6
ER -