Effects of androgen on DNA synthesis in immature rat uteri

Shinobu Sakamoto, Tohru Kawasaki, Shuji Sassa, Akihiko Kumai, Ryohei Okamoto, Yoshie Sugiura, Vinci Mizuhira

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The effects of testosterone and 17β-estradioI on uterine thymidine kinase (TK) activity in immature rats were investigated. Injection of either compound alone resulted in a more than 30-fold increase in TK activity 30 hr later. Injection of the two compounds together resulted in an even greater increase in TK activity and in the activities of its isozymes separated by DEAE cellulose column chromatography. Autoradiographic examination showed that testosterone alone induced marked DNA synthesis in the endometrial stroma and myometrium, but not in the endometrial epithelium, and that its effect on DNA synthesis in all these tissues was enhanced by the additional injection of 17β-estradiol.

Original languageEnglish (US)
Pages (from-to)213-220
Number of pages8
Issue number2
StatePublished - 1985

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Biochemistry
  • Physiology
  • Histology
  • Cell Biology


Dive into the research topics of 'Effects of androgen on DNA synthesis in immature rat uteri'. Together they form a unique fingerprint.

Cite this