Effects of aspirin on gastric mucosal prostaglandin E2 and F2α content and on gastric mucosal injury in humans receiving fish oil or olive oil

Thomas W. Faust; Jan Stephen Redfern; Israel Podolsky; Edward Lee; Scott M Grundy; Mark Feldman

doi:10.1016/0016-5085(90)90277-8

Effects of aspirin on gastric mucosal prostaglandin E₂ and F_2α content and on gastric mucosal injury in humans receiving fish oil or olive oil

Thomas W. Faust, Jan Stephen Redfern, Israel Podolsky, Edward Lee, Scott M Grundy, Mark Feldman

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Abstract

Gastric mucosal prostaglandin E₂ and F_2α content was evaluated in healthy human subjects who received either fish oil or olive oil (control) daily for 3 wk before exposure to aspirin or no aspirin. Two hours after aspirin administration, when mean serum salicylate concentration was ~12 mg/dl, gastric mucosal prostaglandin E₂ and F_2α content was reduced by > 95% in the fundus and antrum (p < 0.001) and there was endoscopic evidence of gastric mucosal damage (erosions, submucosal hemorrhages). Fish oil feeding had no significant effect on mucosal prostaglandin E₂ or F_2α content or on the damaging effect of aspirin on the stomach, despite the fact that fish oil reduced serum triglyceride concentrations significantly. These studies indicate that the damaging effects of aspirin on the gastric mucosa are not influenced by dietary fish oil.

Original language	English (US)
Pages (from-to)	586-591
Number of pages	6
Journal	Gastroenterology
Volume	98
Issue number	3
DOIs	https://doi.org/10.1016/0016-5085(90)90277-8
State	Published - Mar 1990

ASJC Scopus subject areas

Hepatology
Gastroenterology

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10.1016/0016-5085(90)90277-8

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title = "Effects of aspirin on gastric mucosal prostaglandin E2 and F2α content and on gastric mucosal injury in humans receiving fish oil or olive oil",

abstract = "Gastric mucosal prostaglandin E2 and F2α content was evaluated in healthy human subjects who received either fish oil or olive oil (control) daily for 3 wk before exposure to aspirin or no aspirin. Two hours after aspirin administration, when mean serum salicylate concentration was ~12 mg/dl, gastric mucosal prostaglandin E2 and F2α content was reduced by > 95% in the fundus and antrum (p < 0.001) and there was endoscopic evidence of gastric mucosal damage (erosions, submucosal hemorrhages). Fish oil feeding had no significant effect on mucosal prostaglandin E2 or F2α content or on the damaging effect of aspirin on the stomach, despite the fact that fish oil reduced serum triglyceride concentrations significantly. These studies indicate that the damaging effects of aspirin on the gastric mucosa are not influenced by dietary fish oil.",

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AU - Faust, Thomas W.

AU - Redfern, Jan Stephen

AU - Podolsky, Israel

AU - Lee, Edward

AU - Grundy, Scott M

AU - Feldman, Mark

PY - 1990/3

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AB - Gastric mucosal prostaglandin E2 and F2α content was evaluated in healthy human subjects who received either fish oil or olive oil (control) daily for 3 wk before exposure to aspirin or no aspirin. Two hours after aspirin administration, when mean serum salicylate concentration was ~12 mg/dl, gastric mucosal prostaglandin E2 and F2α content was reduced by > 95% in the fundus and antrum (p < 0.001) and there was endoscopic evidence of gastric mucosal damage (erosions, submucosal hemorrhages). Fish oil feeding had no significant effect on mucosal prostaglandin E2 or F2α content or on the damaging effect of aspirin on the stomach, despite the fact that fish oil reduced serum triglyceride concentrations significantly. These studies indicate that the damaging effects of aspirin on the gastric mucosa are not influenced by dietary fish oil.

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Effects of aspirin on gastric mucosal prostaglandin E₂ and F_2α content and on gastric mucosal injury in humans receiving fish oil or olive oil

Abstract

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