Effects of castration and androgen treatment on androgen-receptor levels in rat skeletal muscles

Jose Antonio, Jean D. Wilson, Fredrick W. George

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

The effects of castration and dihydrotestosterone (DHT) treatment on levels of skeletal muscle androgen receptor (AR) were examined in three groups of adult male rats: 1) intact normal rats, 2) rats castrated at 16 wk of age, and 3) rats castrated at 16 wk of age and given DHT for I wk starting at week 17. All animals were killed at 18 wk of age. Castration caused a decrease (P < 0.05) in the weights of the levator ani and bulbocavernosus muscles. The administration of DHT to the castrated rats increased (P < 0.05) the weights of the levator ani and bulbocavernosus muscles. Castration caused a significant downregulation of AR levels in the bulbocavernosus (P < 0.05) but had no significant effect on AR levels in the levator ani muscle. DHT administration to the castrated group upregulated AR levels in the bulbocavernosus and levator ani muscles. The plantaris muscle did not significantly (P > 0.05) change for any of the treatments. These findings suggest that the effects of castration and androgen replacement differentially affect skeletal muscle mass and AR levels.

Original languageEnglish (US)
Pages (from-to)2016-2019
Number of pages4
JournalJournal of Applied Physiology
Volume87
Issue number6
StatePublished - Dec 1999

Fingerprint

Castration
Androgen Receptors
Androgens
Skeletal Muscle
Dihydrotestosterone

Keywords

  • Anabolic steroid
  • Growth
  • Muscle fiber
  • Myofiber
  • Steroids

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Effects of castration and androgen treatment on androgen-receptor levels in rat skeletal muscles. / Antonio, Jose; Wilson, Jean D.; George, Fredrick W.

In: Journal of Applied Physiology, Vol. 87, No. 6, 12.1999, p. 2016-2019.

Research output: Contribution to journalArticle

Antonio, Jose ; Wilson, Jean D. ; George, Fredrick W. / Effects of castration and androgen treatment on androgen-receptor levels in rat skeletal muscles. In: Journal of Applied Physiology. 1999 ; Vol. 87, No. 6. pp. 2016-2019.
@article{9b24db2f22b9463bb6aedfca4fb8f347,
title = "Effects of castration and androgen treatment on androgen-receptor levels in rat skeletal muscles",
abstract = "The effects of castration and dihydrotestosterone (DHT) treatment on levels of skeletal muscle androgen receptor (AR) were examined in three groups of adult male rats: 1) intact normal rats, 2) rats castrated at 16 wk of age, and 3) rats castrated at 16 wk of age and given DHT for I wk starting at week 17. All animals were killed at 18 wk of age. Castration caused a decrease (P < 0.05) in the weights of the levator ani and bulbocavernosus muscles. The administration of DHT to the castrated rats increased (P < 0.05) the weights of the levator ani and bulbocavernosus muscles. Castration caused a significant downregulation of AR levels in the bulbocavernosus (P < 0.05) but had no significant effect on AR levels in the levator ani muscle. DHT administration to the castrated group upregulated AR levels in the bulbocavernosus and levator ani muscles. The plantaris muscle did not significantly (P > 0.05) change for any of the treatments. These findings suggest that the effects of castration and androgen replacement differentially affect skeletal muscle mass and AR levels.",
keywords = "Anabolic steroid, Growth, Muscle fiber, Myofiber, Steroids",
author = "Jose Antonio and Wilson, {Jean D.} and George, {Fredrick W.}",
year = "1999",
month = "12",
language = "English (US)",
volume = "87",
pages = "2016--2019",
journal = "Journal of Applied Physiology",
issn = "0161-7567",
publisher = "American Physiological Society",
number = "6",

}

TY - JOUR

T1 - Effects of castration and androgen treatment on androgen-receptor levels in rat skeletal muscles

AU - Antonio, Jose

AU - Wilson, Jean D.

AU - George, Fredrick W.

PY - 1999/12

Y1 - 1999/12

N2 - The effects of castration and dihydrotestosterone (DHT) treatment on levels of skeletal muscle androgen receptor (AR) were examined in three groups of adult male rats: 1) intact normal rats, 2) rats castrated at 16 wk of age, and 3) rats castrated at 16 wk of age and given DHT for I wk starting at week 17. All animals were killed at 18 wk of age. Castration caused a decrease (P < 0.05) in the weights of the levator ani and bulbocavernosus muscles. The administration of DHT to the castrated rats increased (P < 0.05) the weights of the levator ani and bulbocavernosus muscles. Castration caused a significant downregulation of AR levels in the bulbocavernosus (P < 0.05) but had no significant effect on AR levels in the levator ani muscle. DHT administration to the castrated group upregulated AR levels in the bulbocavernosus and levator ani muscles. The plantaris muscle did not significantly (P > 0.05) change for any of the treatments. These findings suggest that the effects of castration and androgen replacement differentially affect skeletal muscle mass and AR levels.

AB - The effects of castration and dihydrotestosterone (DHT) treatment on levels of skeletal muscle androgen receptor (AR) were examined in three groups of adult male rats: 1) intact normal rats, 2) rats castrated at 16 wk of age, and 3) rats castrated at 16 wk of age and given DHT for I wk starting at week 17. All animals were killed at 18 wk of age. Castration caused a decrease (P < 0.05) in the weights of the levator ani and bulbocavernosus muscles. The administration of DHT to the castrated rats increased (P < 0.05) the weights of the levator ani and bulbocavernosus muscles. Castration caused a significant downregulation of AR levels in the bulbocavernosus (P < 0.05) but had no significant effect on AR levels in the levator ani muscle. DHT administration to the castrated group upregulated AR levels in the bulbocavernosus and levator ani muscles. The plantaris muscle did not significantly (P > 0.05) change for any of the treatments. These findings suggest that the effects of castration and androgen replacement differentially affect skeletal muscle mass and AR levels.

KW - Anabolic steroid

KW - Growth

KW - Muscle fiber

KW - Myofiber

KW - Steroids

UR - http://www.scopus.com/inward/record.url?scp=0032795734&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032795734&partnerID=8YFLogxK

M3 - Article

VL - 87

SP - 2016

EP - 2019

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 0161-7567

IS - 6

ER -