Effects of Chinese herbal medicines on DNA-synthesizing enzyme activities in mammary tumors of mice.

S. Sakamoto, R. Furuichi, M. Matsuda, H. Kudo, S. Suzuki, Y. Sugiura, K. Kuwa, M. Tajima, M. Matsubara, H. Namiki

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1 Scopus citations

Abstract

Sho-saiko-to (SST) and Juzen-taiho-to (JTT), Japanese modified Chinese herbal prescriptions, suppressed the activities of thymidylate synthetase and thymidine kinase involved in de novo and salvage pathways for pyrimidine nucleotide synthesis, respectively, in mammary tumors of SHN mice with the reduction of serum prolactin level. These results indicate that SST and JTT may have the antitumor effects on mammary tumors.

Original languageEnglish (US)
Pages (from-to)43-50
Number of pages8
JournalThe American journal of Chinese medicine
Volume22
Issue number1
DOIs
StatePublished - 1994

ASJC Scopus subject areas

  • Complementary and alternative medicine

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    Sakamoto, S., Furuichi, R., Matsuda, M., Kudo, H., Suzuki, S., Sugiura, Y., Kuwa, K., Tajima, M., Matsubara, M., & Namiki, H. (1994). Effects of Chinese herbal medicines on DNA-synthesizing enzyme activities in mammary tumors of mice. The American journal of Chinese medicine, 22(1), 43-50. https://doi.org/10.1142/s0192415x94000061