Effects of chloramine-T on activation and inactivation of sodium channels in neuroblastoma cells

E. D. Nosyreva, I. I. Grishchenko, Yu A. Negulyaev

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2 Scopus citations

Abstract

The effects of chloramine-T, a reagent specific to methionine residues, on sodium channel gating mechanisms was investigated in neuroblastoma cell membrane. Treating the membrane with chloramine was found to retard inactivation kinetics and considerably reduce the slope of the inactivation curve, while pushing the activation curve toward hyperpolarization ranges without changing the slope of the central portion perceptibly. Effective activation charge, as determined from the limiting logarithmic slope of activation, was reduced by a factor of 1.17. Possible reasons for the changes observed in sodium channel gating mechanisms are discussed.

Original languageEnglish (US)
Pages (from-to)574-579
Number of pages6
JournalNeurophysiology
Volume19
Issue number6
DOIs
StatePublished - Nov 1987

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ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

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