Effects of Chlorothiazide on Plasma Electrolytes in the Nephrectomized Dog

W. R. Beavers

Research output: Contribution to journalArticle

Abstract

Chlorothiazide and hydrochlorothiazide significantly lowered plasma potassium levels in the nephrectomized dog after intravenous administration. Mercaptomerin and acetazolamide had had no such effect. Plasma sodium concentrations were not altered and no differential effects on pH, hematocrit, or blood pressure were seen in any groups of animals. These findings suggest that chlorothiazide and hydrochlorothiazide have an extrarenal effect not shared by mercaptomerin or acetazolamide.

Original languageEnglish (US)
Pages (from-to)711-712
Number of pages2
JournalProceedings of the Society for Experimental Biology and Medicine
Volume103
Issue number4
DOIs
StatePublished - 1960

Fingerprint

Chlorothiazide
Acetazolamide
Hydrochlorothiazide
Electrolytes
Dogs
Plasmas
Blood pressure
Hematocrit
Intravenous Administration
Potassium
Animals
Sodium
Blood Pressure
mercaptomerin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Effects of Chlorothiazide on Plasma Electrolytes in the Nephrectomized Dog. / Beavers, W. R.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 103, No. 4, 1960, p. 711-712.

Research output: Contribution to journalArticle

@article{af05d6ad6a8142a69aaf8e0b59ec77ce,
title = "Effects of Chlorothiazide on Plasma Electrolytes in the Nephrectomized Dog",
abstract = "Chlorothiazide and hydrochlorothiazide significantly lowered plasma potassium levels in the nephrectomized dog after intravenous administration. Mercaptomerin and acetazolamide had had no such effect. Plasma sodium concentrations were not altered and no differential effects on pH, hematocrit, or blood pressure were seen in any groups of animals. These findings suggest that chlorothiazide and hydrochlorothiazide have an extrarenal effect not shared by mercaptomerin or acetazolamide.",
author = "Beavers, {W. R.}",
year = "1960",
doi = "10.3181/00379727-103-25644",
language = "English (US)",
volume = "103",
pages = "711--712",
journal = "Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)",
issn = "1535-3702",
publisher = "SAGE Publications Ltd",
number = "4",

}

TY - JOUR

T1 - Effects of Chlorothiazide on Plasma Electrolytes in the Nephrectomized Dog

AU - Beavers, W. R.

PY - 1960

Y1 - 1960

N2 - Chlorothiazide and hydrochlorothiazide significantly lowered plasma potassium levels in the nephrectomized dog after intravenous administration. Mercaptomerin and acetazolamide had had no such effect. Plasma sodium concentrations were not altered and no differential effects on pH, hematocrit, or blood pressure were seen in any groups of animals. These findings suggest that chlorothiazide and hydrochlorothiazide have an extrarenal effect not shared by mercaptomerin or acetazolamide.

AB - Chlorothiazide and hydrochlorothiazide significantly lowered plasma potassium levels in the nephrectomized dog after intravenous administration. Mercaptomerin and acetazolamide had had no such effect. Plasma sodium concentrations were not altered and no differential effects on pH, hematocrit, or blood pressure were seen in any groups of animals. These findings suggest that chlorothiazide and hydrochlorothiazide have an extrarenal effect not shared by mercaptomerin or acetazolamide.

UR - http://www.scopus.com/inward/record.url?scp=72849163859&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=72849163859&partnerID=8YFLogxK

U2 - 10.3181/00379727-103-25644

DO - 10.3181/00379727-103-25644

M3 - Article

C2 - 13797987

AN - SCOPUS:72849163859

VL - 103

SP - 711

EP - 712

JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)

JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)

SN - 1535-3702

IS - 4

ER -