Effects of Chlorothiazide on Plasma Electrolytes in the Nephrectomized Dog

W. R. Beavers

doi:10.3181/00379727-103-25644

Effects of Chlorothiazide on Plasma Electrolytes in the Nephrectomized Dog

W. R. Beavers

Research output: Contribution to journal › Article › peer-review

Abstract

Chlorothiazide and hydrochlorothiazide significantly lowered plasma potassium levels in the nephrectomized dog after intravenous administration. Mercaptomerin and acetazolamide had had no such effect. Plasma sodium concentrations were not altered and no differential effects on pH, hematocrit, or blood pressure were seen in any groups of animals. These findings suggest that chlorothiazide and hydrochlorothiazide have an extrarenal effect not shared by mercaptomerin or acetazolamide.

Original language	English (US)
Pages (from-to)	711-712
Number of pages	2
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	103
Issue number	4
DOIs	https://doi.org/10.3181/00379727-103-25644
State	Published - Apr 1960

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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abstract = "Chlorothiazide and hydrochlorothiazide significantly lowered plasma potassium levels in the nephrectomized dog after intravenous administration. Mercaptomerin and acetazolamide had had no such effect. Plasma sodium concentrations were not altered and no differential effects on pH, hematocrit, or blood pressure were seen in any groups of animals. These findings suggest that chlorothiazide and hydrochlorothiazide have an extrarenal effect not shared by mercaptomerin or acetazolamide.",

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Effects of Chlorothiazide on Plasma Electrolytes in the Nephrectomized Dog

Abstract

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