Abstract
HYPOTHESIS: Exposure to ciprofloxacin/dexamethasone, but not ofloxacin, prolongs tympanic membrane (TM) healing. BACKGROUND: Exposure to hydrocortisone has been shown to delay TM wound healing. No published studies have compared the effects of ciprofloxacin/dexamethasone and ofloxacin on TM healing. METHODS: Noninfected TM perforations were created in 30 rats. The rats were split into three groups, and ciprofloxacin/dexamethasone, ofloxacin, or isotonic sodium chloride solution drops were instilled for 8 days. Tympanic membrane healing was analyzed at specified intervals using photographic documentation verified by a blinded observer. RESULTS: The isotonic sodium chloride solution control and ofloxacin-exposed TMs healed at similar rates. There was a statistically significant delay in TM healing in the ciprofloxacin-/dexamethasone-exposed TMs by postoperative Day 10. However, all TM perforations were healed by postoperative Day 20. CONCLUSION: Ciprofloxacin/dexamethasone delays healing of experimental TM perforations, but the brief exposure in this study did not cause persistent perforations.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 887-890 |
| Number of pages | 4 |
| Journal | Otology and Neurotology |
| Volume | 28 |
| Issue number | 7 |
| DOIs | |
| State | Published - Oct 2007 |
Keywords
- Ciprodex
- Ciprofloxacin/dexamethasone
- Corticosteroids
- Floxin
- Glucocorticoids
- Ofloxacin
- Perforation
- Tympanic membrane
- Wound healing
ASJC Scopus subject areas
- Otorhinolaryngology
- Sensory Systems
- Clinical Neurology