Effects of clonidine on 24-hour hormonal secretory patterns, cardiovascular hemodynamics, and central nervous function in hypertensive adolescents

R. M. Boyar, David E Fixler, Norman M Kaplan, R. M. Graham, K. P. Price, J. J. Chipman, W. P. Laird

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

To assess the potential of antihypertensive drugs for interference with somatic growth and sexual development in hypertensive children, the effect of clonidine therapy on various endocrine, cardiovascular, and neuromuscular functions has been examined in five male adolescents with idiopathic hypertension. In studies done before and at the end of 4 weeks of twice-daily clonidine therapy, in an average daily dose of 0.31 mg, no significant effects were noted in the secretory patterns of growth hormone, luteinizing hormone, folliclestimulating hormone, prolac'tin, cortisol, aldosterone, or testosterone, measured in blood obtained every 20 minutes for 24 hours. In blood obtained while the patients were supine and then erect, plasma renin activity and norepinephrine levels were significantly lowered after clonidine therapy. Cardiovascular responses to dynamic exercise were little altered beyond a 17% decrease in maximal oxygen consumption. The performance of fine motor skills was minimally altered. These data provide preliminary evidence that clonidine, an antihypertensive drug that affects the adrenergic nervous system, may not interfere with normal growth and maturation in adolescent males.

Original languageEnglish (US)
Pages (from-to)83-89
Number of pages7
JournalHypertension
Volume2
Issue number1
DOIs
StatePublished - Jan 1 1980

Keywords

  • Adolescents
  • Clonidine therapy
  • Hormonal secretion hemodynamics
  • Idiopathic hypertension

ASJC Scopus subject areas

  • Internal Medicine

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