Effects of combined exposure to aluminium and ethanol on food intake, motor behaviour and a few biochemical parameters in pubertal rats

Karthik Rajasekaran

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Combined daily administration of aluminium chloride (260 mg/kg, oral) and ethanol (2 g/kg, oral), to pubertal male rats for 30 days was found to significantly decrease food intake, body weight gain and serum protein levels. Spontaneous motor activity and rota-rod motor coordination were also significantly impaired. Acetylcholinesterase activity was significantly diminished in the cerebrum and cerebellum. The results obtained in the present study are suggestive of a potentiation of cholinotoxic effects of the two compounds when administered together. Thus, when combined, ethanol may increase pubertal rat's susceptibility to the toxic effects of aluminium.

Original languageEnglish (US)
Pages (from-to)25-30
Number of pages6
JournalEnvironmental Toxicology and Pharmacology
Volume9
Issue number1-2
DOIs
StatePublished - 2000

Fingerprint

Aluminum
Rats
Ethanol
Eating
Poisons
Cerebrum
Acetylcholinesterase
Cerebellum
Weight Gain
Blood Proteins
Motor Activity
Body Weight
aluminum chloride

Keywords

  • Acetylcholinesterase activity
  • Aluminium
  • Ethanol
  • Food intake
  • Motor coordination
  • Serum protein
  • Spontaneous motor activity

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis
  • Pharmacology

Cite this

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abstract = "Combined daily administration of aluminium chloride (260 mg/kg, oral) and ethanol (2 g/kg, oral), to pubertal male rats for 30 days was found to significantly decrease food intake, body weight gain and serum protein levels. Spontaneous motor activity and rota-rod motor coordination were also significantly impaired. Acetylcholinesterase activity was significantly diminished in the cerebrum and cerebellum. The results obtained in the present study are suggestive of a potentiation of cholinotoxic effects of the two compounds when administered together. Thus, when combined, ethanol may increase pubertal rat's susceptibility to the toxic effects of aluminium.",
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AB - Combined daily administration of aluminium chloride (260 mg/kg, oral) and ethanol (2 g/kg, oral), to pubertal male rats for 30 days was found to significantly decrease food intake, body weight gain and serum protein levels. Spontaneous motor activity and rota-rod motor coordination were also significantly impaired. Acetylcholinesterase activity was significantly diminished in the cerebrum and cerebellum. The results obtained in the present study are suggestive of a potentiation of cholinotoxic effects of the two compounds when administered together. Thus, when combined, ethanol may increase pubertal rat's susceptibility to the toxic effects of aluminium.

KW - Acetylcholinesterase activity

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KW - Ethanol

KW - Food intake

KW - Motor coordination

KW - Serum protein

KW - Spontaneous motor activity

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