TY - JOUR
T1 - Effects of combined exposure to aluminium and ethanol on food intake, motor behaviour and a few biochemical parameters in pubertal rats
AU - Rajasekaran, Karthik
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 2000
Y1 - 2000
N2 - Combined daily administration of aluminium chloride (260 mg/kg, oral) and ethanol (2 g/kg, oral), to pubertal male rats for 30 days was found to significantly decrease food intake, body weight gain and serum protein levels. Spontaneous motor activity and rota-rod motor coordination were also significantly impaired. Acetylcholinesterase activity was significantly diminished in the cerebrum and cerebellum. The results obtained in the present study are suggestive of a potentiation of cholinotoxic effects of the two compounds when administered together. Thus, when combined, ethanol may increase pubertal rat's susceptibility to the toxic effects of aluminium.
AB - Combined daily administration of aluminium chloride (260 mg/kg, oral) and ethanol (2 g/kg, oral), to pubertal male rats for 30 days was found to significantly decrease food intake, body weight gain and serum protein levels. Spontaneous motor activity and rota-rod motor coordination were also significantly impaired. Acetylcholinesterase activity was significantly diminished in the cerebrum and cerebellum. The results obtained in the present study are suggestive of a potentiation of cholinotoxic effects of the two compounds when administered together. Thus, when combined, ethanol may increase pubertal rat's susceptibility to the toxic effects of aluminium.
KW - Acetylcholinesterase activity
KW - Aluminium
KW - Ethanol
KW - Food intake
KW - Motor coordination
KW - Serum protein
KW - Spontaneous motor activity
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U2 - 10.1016/S1382-6689(00)00058-2
DO - 10.1016/S1382-6689(00)00058-2
M3 - Article
AN - SCOPUS:0034536218
SN - 1382-6689
VL - 9
SP - 25
EP - 30
JO - Environmental Toxicology and Pharmacology
JF - Environmental Toxicology and Pharmacology
IS - 1-2
ER -