Combined daily administration of aluminium chloride (260 mg/kg, oral) and ethanol (2 g/kg, oral), to pubertal male rats for 30 days was found to significantly decrease food intake, body weight gain and serum protein levels. Spontaneous motor activity and rota-rod motor coordination were also significantly impaired. Acetylcholinesterase activity was significantly diminished in the cerebrum and cerebellum. The results obtained in the present study are suggestive of a potentiation of cholinotoxic effects of the two compounds when administered together. Thus, when combined, ethanol may increase pubertal rat's susceptibility to the toxic effects of aluminium.
- Acetylcholinesterase activity
- Food intake
- Motor coordination
- Serum protein
- Spontaneous motor activity
ASJC Scopus subject areas
- Health, Toxicology and Mutagenesis