TY - JOUR
T1 - Effects of danazol on DNA synthesis in rat prostate
AU - Sakamoto, S.
AU - Mori, T.
AU - Sawaki, K.
AU - Sassa, S.
AU - Suzuki, S.
AU - Sugiura, Y.
AU - Kudo, H.
AU - Kasahara, N.
AU - Nagasawa, H.
PY - 1993
Y1 - 1993
N2 - Effects of danazol, an isoxazol derivative of the synthetic steroid 17α‐ethinyltestosterone, on activities of thymidylate synthetase and thymidine kinase, which are the DNA‐synthesizing enzymes included in de novo and salvage pathways of pyrimidine metabolism, respectively, were investigated in rat prostate. Danazol markedly reduced plasma levels of luteinizing hormone and testosterone, and organ weight, both enzyme activities and bro‐modeoxyuridine‐immunoreactive cells which were regarded as the S‐phase cells in prostate. These results indicate that danazol shows a property as a potent antigonadotropin. © 1993 Wiley‐Liss, Inc.
AB - Effects of danazol, an isoxazol derivative of the synthetic steroid 17α‐ethinyltestosterone, on activities of thymidylate synthetase and thymidine kinase, which are the DNA‐synthesizing enzymes included in de novo and salvage pathways of pyrimidine metabolism, respectively, were investigated in rat prostate. Danazol markedly reduced plasma levels of luteinizing hormone and testosterone, and organ weight, both enzyme activities and bro‐modeoxyuridine‐immunoreactive cells which were regarded as the S‐phase cells in prostate. These results indicate that danazol shows a property as a potent antigonadotropin. © 1993 Wiley‐Liss, Inc.
KW - DNA‐synthesizing enzyme
KW - danazol
KW - prostate
UR - http://www.scopus.com/inward/record.url?scp=0027412778&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027412778&partnerID=8YFLogxK
U2 - 10.1002/pros.2990220204
DO - 10.1002/pros.2990220204
M3 - Article
C2 - 8456051
AN - SCOPUS:0027412778
VL - 22
SP - 119
EP - 124
JO - Prostate
JF - Prostate
SN - 0270-4137
IS - 2
ER -