Effects of danazol on DNA synthesis in rat prostate

S. Sakamoto, T. Mori, K. Sawaki, S. Sassa, S. Suzuki, Y. Sugiura, H. Kudo, N. Kasahara, H. Nagasawa

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3 Scopus citations

Abstract

Effects of danazol, an isoxazol derivative of the synthetic steroid 17α‐ethinyltestosterone, on activities of thymidylate synthetase and thymidine kinase, which are the DNA‐synthesizing enzymes included in de novo and salvage pathways of pyrimidine metabolism, respectively, were investigated in rat prostate. Danazol markedly reduced plasma levels of luteinizing hormone and testosterone, and organ weight, both enzyme activities and bro‐modeoxyuridine‐immunoreactive cells which were regarded as the S‐phase cells in prostate. These results indicate that danazol shows a property as a potent antigonadotropin. © 1993 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)119-124
Number of pages6
JournalThe Prostate
Volume22
Issue number2
DOIs
StatePublished - 1993

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Keywords

  • DNA‐synthesizing enzyme
  • danazol
  • prostate

ASJC Scopus subject areas

  • Oncology
  • Urology

Cite this

Sakamoto, S., Mori, T., Sawaki, K., Sassa, S., Suzuki, S., Sugiura, Y., Kudo, H., Kasahara, N., & Nagasawa, H. (1993). Effects of danazol on DNA synthesis in rat prostate. The Prostate, 22(2), 119-124. https://doi.org/10.1002/pros.2990220204