Effects of Danazol on endometrial DNA synthesis in rats

Satoe Suzuki, Shinobu Sakamoto, Hideki Kudo, Shuji Sassa, Yoshie Sugiura, Katsuhiko Kuwa, Noriyuki Kasahara, Takao Mori, Hiroshi Nagasawa

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The suppressive effects of Danazol, an isoxazol derivative of the synthetic steroid 17 α-ethinyltestosterone, on endometrial DNA synthesis were investigated in rats by immunohistochemistry with bromodeoxyuridine (BrdU) and DNA-synthesizing enzyme assays. Rats treated with Danazol for 14 days at 17-19 weeks of age showed a decrease of plasma gonadotropins associated with ovarian hypofunction, persistent diestrus, and a smaller number of corpora lutea in ovary, resulting in no BrdU-immunoreactive (S-phase) cells in endometrial epithelium and lower activity of thymidine kinase in the uterus compared with control.

Original languageEnglish (US)
Pages (from-to)551-553
Number of pages3
JournalSteroids
Volume58
Issue number11
DOIs
StatePublished - Nov 1993

Keywords

  • DNA synthesis
  • Danazol
  • endometrium

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology
  • Pharmacology
  • Clinical Biochemistry
  • Organic Chemistry

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