Effects of Danazol on endometrial DNA synthesis in rats

Satoe Suzuki, Shinobu Sakamoto, Hideki Kudo, Shuji Sassa, Yoshie Sugiura, Katsuhiko Kuwa, Noriyuki Kasahara, Takao Mori, Hiroshi Nagasawa

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Abstract

The suppressive effects of Danazol, an isoxazol derivative of the synthetic steroid 17 α-ethinyltestosterone, on endometrial DNA synthesis were investigated in rats by immunohistochemistry with bromodeoxyuridine (BrdU) and DNA-synthesizing enzyme assays. Rats treated with Danazol for 14 days at 17-19 weeks of age showed a decrease of plasma gonadotropins associated with ovarian hypofunction, persistent diestrus, and a smaller number of corpora lutea in ovary, resulting in no BrdU-immunoreactive (S-phase) cells in endometrial epithelium and lower activity of thymidine kinase in the uterus compared with control.

Original languageEnglish (US)
Pages (from-to)551-553
Number of pages3
JournalSteroids
Volume58
Issue number11
DOIs
Publication statusPublished - 1993

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Keywords

  • Danazol
  • DNA synthesis
  • endometrium

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Molecular Biology

Cite this

Suzuki, S., Sakamoto, S., Kudo, H., Sassa, S., Sugiura, Y., Kuwa, K., ... Nagasawa, H. (1993). Effects of Danazol on endometrial DNA synthesis in rats. Steroids, 58(11), 551-553. https://doi.org/10.1016/0039-128X(93)90034-K