Effects of Danazol on thrombopoiesis in rats

S. Suzuki, H. Kudo, T. Nakayama, K. Kuwa, Y. Sugiura, L. Liu, S. Sakamoto

Research output: Contribution to journalArticle

Abstract

A synthetic analog of ethinyltestosterone, Danazol, has been used clinically for the treatment of immune thrombocytopenia. We investigated the effects of Danazol on thrombopoiesis in normal rats. Though 4-week treatment by Danazol slightly enhanced the DNA synthesizing enzyme activities and the number of S-phase cells in bone marrow and spleen, the number of megakaryocytes and thrombocytes were not increased in bone marrow and peripheral blood, respectively. These findings suggest that Danazol treatment will not induce thrombosis with thrombocytosis in normal human beings and animals.

Original languageEnglish (US)
Pages (from-to)1003-1005
Number of pages3
JournalIn Vivo
Volume8
Issue number6
StatePublished - Dec 1 1994

Keywords

  • Danazol
  • Rat
  • Thrombopoiesis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

Fingerprint Dive into the research topics of 'Effects of Danazol on thrombopoiesis in rats'. Together they form a unique fingerprint.

  • Cite this

    Suzuki, S., Kudo, H., Nakayama, T., Kuwa, K., Sugiura, Y., Liu, L., & Sakamoto, S. (1994). Effects of Danazol on thrombopoiesis in rats. In Vivo, 8(6), 1003-1005.