Effects of dehydration on cerebrovascular control during standing after heavy resistance exercise

Gilbert Moralez, Steven A. Romero, Caroline A. Rickards, Kathy L. Ryan, Victor A. Convertino, William H. Cooke

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Effects of dehydration on cerebrovascular control during standing after heavy resistance exercise. J Appl Physiol 112: 1875-1883, 2012. First published March 29, 2012; doi:10.1152/japplphysiol.01217.2011.-We tested the hypothesis that dehydration exacerbates reductions of middle cerebral artery blood velocity (MCAv) and alters cerebrovascular control during standing after heavy resistance exercise. Ten males participated in two trials under 1) euhydration (EUH) and 2) dehydration (DEH; fluid restriction + 40 mg furosemide). We recorded finger photoplethysmographic arterial pressure and MCAv (transcranial Doppler) during 10 min of standing immediately after high-intensity leg press exercise. Symptoms (e.g., lightheadedness) were ranked by subjects during standing (1-5 scale). Low-frequency (LF) oscillations of mean arterial pressure (MAP) and mean MCAv were calculated as indicators of cerebrovascular control. DEH reduced plasma volume by 11% (P = 0.002; calculated from hemoglobin and hematocrit). During the first 30 s of standing after exercise, subjects reported greater symptoms during DEH vs. EUH (P = 0.05), but these were mild and resolved at 60 s. While MAP decreased similarly between conditions immediately after standing, MCAv decreased more with DEH than EUH (P = 0.02). With prolonged standing under DEH, mean MCAv remained below baseline (P ≤ 0.01), and below EUH values (P ≤ 0.05). LF oscillations of MAP were higher for DEH at baseline and during the entire 10 min of stand after exercise (P ≤ 0.057), while LF oscillations in mean MCAv were distinguishable only at baseline and 5 min following stand (P = 0.05). Our results suggest that mean MCAv falls below a "symptomatic threshold" in the acute phase of standing after exercise during DEH, although symptoms were mild and transient. During the prolonged phase of standing, increases in LF MAP and mean MCAv oscillations with DEH may help to maintain cerebral perfusion despite absolute MCAv remaining below the symptomatic threshold.

Original languageEnglish (US)
Pages (from-to)1875-1883
Number of pages9
JournalJournal of applied physiology
Volume112
Issue number11
DOIs
StatePublished - Jun 1 2012
Externally publishedYes

Fingerprint

Middle Cerebral Artery
Dehydration
Arterial Pressure
Plasma Volume
Furosemide
Dizziness
Hematocrit
Fingers
Leg
Hemoglobins
Perfusion

Keywords

  • Cerebral blood flow
  • Cerebrovascular control
  • Hypohydration
  • Weight training

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Effects of dehydration on cerebrovascular control during standing after heavy resistance exercise. / Moralez, Gilbert; Romero, Steven A.; Rickards, Caroline A.; Ryan, Kathy L.; Convertino, Victor A.; Cooke, William H.

In: Journal of applied physiology, Vol. 112, No. 11, 01.06.2012, p. 1875-1883.

Research output: Contribution to journalArticle

Moralez, Gilbert ; Romero, Steven A. ; Rickards, Caroline A. ; Ryan, Kathy L. ; Convertino, Victor A. ; Cooke, William H. / Effects of dehydration on cerebrovascular control during standing after heavy resistance exercise. In: Journal of applied physiology. 2012 ; Vol. 112, No. 11. pp. 1875-1883.
@article{b57c15457f58477f984133c8d2e6a8b4,
title = "Effects of dehydration on cerebrovascular control during standing after heavy resistance exercise",
abstract = "Effects of dehydration on cerebrovascular control during standing after heavy resistance exercise. J Appl Physiol 112: 1875-1883, 2012. First published March 29, 2012; doi:10.1152/japplphysiol.01217.2011.-We tested the hypothesis that dehydration exacerbates reductions of middle cerebral artery blood velocity (MCAv) and alters cerebrovascular control during standing after heavy resistance exercise. Ten males participated in two trials under 1) euhydration (EUH) and 2) dehydration (DEH; fluid restriction + 40 mg furosemide). We recorded finger photoplethysmographic arterial pressure and MCAv (transcranial Doppler) during 10 min of standing immediately after high-intensity leg press exercise. Symptoms (e.g., lightheadedness) were ranked by subjects during standing (1-5 scale). Low-frequency (LF) oscillations of mean arterial pressure (MAP) and mean MCAv were calculated as indicators of cerebrovascular control. DEH reduced plasma volume by 11{\%} (P = 0.002; calculated from hemoglobin and hematocrit). During the first 30 s of standing after exercise, subjects reported greater symptoms during DEH vs. EUH (P = 0.05), but these were mild and resolved at 60 s. While MAP decreased similarly between conditions immediately after standing, MCAv decreased more with DEH than EUH (P = 0.02). With prolonged standing under DEH, mean MCAv remained below baseline (P ≤ 0.01), and below EUH values (P ≤ 0.05). LF oscillations of MAP were higher for DEH at baseline and during the entire 10 min of stand after exercise (P ≤ 0.057), while LF oscillations in mean MCAv were distinguishable only at baseline and 5 min following stand (P = 0.05). Our results suggest that mean MCAv falls below a {"}symptomatic threshold{"} in the acute phase of standing after exercise during DEH, although symptoms were mild and transient. During the prolonged phase of standing, increases in LF MAP and mean MCAv oscillations with DEH may help to maintain cerebral perfusion despite absolute MCAv remaining below the symptomatic threshold.",
keywords = "Cerebral blood flow, Cerebrovascular control, Hypohydration, Weight training",
author = "Gilbert Moralez and Romero, {Steven A.} and Rickards, {Caroline A.} and Ryan, {Kathy L.} and Convertino, {Victor A.} and Cooke, {William H.}",
year = "2012",
month = "6",
day = "1",
doi = "10.1152/japplphysiol.01217.2011",
language = "English (US)",
volume = "112",
pages = "1875--1883",
journal = "Journal of Applied Physiology",
issn = "0161-7567",
publisher = "American Physiological Society",
number = "11",

}

TY - JOUR

T1 - Effects of dehydration on cerebrovascular control during standing after heavy resistance exercise

AU - Moralez, Gilbert

AU - Romero, Steven A.

AU - Rickards, Caroline A.

AU - Ryan, Kathy L.

AU - Convertino, Victor A.

AU - Cooke, William H.

PY - 2012/6/1

Y1 - 2012/6/1

N2 - Effects of dehydration on cerebrovascular control during standing after heavy resistance exercise. J Appl Physiol 112: 1875-1883, 2012. First published March 29, 2012; doi:10.1152/japplphysiol.01217.2011.-We tested the hypothesis that dehydration exacerbates reductions of middle cerebral artery blood velocity (MCAv) and alters cerebrovascular control during standing after heavy resistance exercise. Ten males participated in two trials under 1) euhydration (EUH) and 2) dehydration (DEH; fluid restriction + 40 mg furosemide). We recorded finger photoplethysmographic arterial pressure and MCAv (transcranial Doppler) during 10 min of standing immediately after high-intensity leg press exercise. Symptoms (e.g., lightheadedness) were ranked by subjects during standing (1-5 scale). Low-frequency (LF) oscillations of mean arterial pressure (MAP) and mean MCAv were calculated as indicators of cerebrovascular control. DEH reduced plasma volume by 11% (P = 0.002; calculated from hemoglobin and hematocrit). During the first 30 s of standing after exercise, subjects reported greater symptoms during DEH vs. EUH (P = 0.05), but these were mild and resolved at 60 s. While MAP decreased similarly between conditions immediately after standing, MCAv decreased more with DEH than EUH (P = 0.02). With prolonged standing under DEH, mean MCAv remained below baseline (P ≤ 0.01), and below EUH values (P ≤ 0.05). LF oscillations of MAP were higher for DEH at baseline and during the entire 10 min of stand after exercise (P ≤ 0.057), while LF oscillations in mean MCAv were distinguishable only at baseline and 5 min following stand (P = 0.05). Our results suggest that mean MCAv falls below a "symptomatic threshold" in the acute phase of standing after exercise during DEH, although symptoms were mild and transient. During the prolonged phase of standing, increases in LF MAP and mean MCAv oscillations with DEH may help to maintain cerebral perfusion despite absolute MCAv remaining below the symptomatic threshold.

AB - Effects of dehydration on cerebrovascular control during standing after heavy resistance exercise. J Appl Physiol 112: 1875-1883, 2012. First published March 29, 2012; doi:10.1152/japplphysiol.01217.2011.-We tested the hypothesis that dehydration exacerbates reductions of middle cerebral artery blood velocity (MCAv) and alters cerebrovascular control during standing after heavy resistance exercise. Ten males participated in two trials under 1) euhydration (EUH) and 2) dehydration (DEH; fluid restriction + 40 mg furosemide). We recorded finger photoplethysmographic arterial pressure and MCAv (transcranial Doppler) during 10 min of standing immediately after high-intensity leg press exercise. Symptoms (e.g., lightheadedness) were ranked by subjects during standing (1-5 scale). Low-frequency (LF) oscillations of mean arterial pressure (MAP) and mean MCAv were calculated as indicators of cerebrovascular control. DEH reduced plasma volume by 11% (P = 0.002; calculated from hemoglobin and hematocrit). During the first 30 s of standing after exercise, subjects reported greater symptoms during DEH vs. EUH (P = 0.05), but these were mild and resolved at 60 s. While MAP decreased similarly between conditions immediately after standing, MCAv decreased more with DEH than EUH (P = 0.02). With prolonged standing under DEH, mean MCAv remained below baseline (P ≤ 0.01), and below EUH values (P ≤ 0.05). LF oscillations of MAP were higher for DEH at baseline and during the entire 10 min of stand after exercise (P ≤ 0.057), while LF oscillations in mean MCAv were distinguishable only at baseline and 5 min following stand (P = 0.05). Our results suggest that mean MCAv falls below a "symptomatic threshold" in the acute phase of standing after exercise during DEH, although symptoms were mild and transient. During the prolonged phase of standing, increases in LF MAP and mean MCAv oscillations with DEH may help to maintain cerebral perfusion despite absolute MCAv remaining below the symptomatic threshold.

KW - Cerebral blood flow

KW - Cerebrovascular control

KW - Hypohydration

KW - Weight training

UR - http://www.scopus.com/inward/record.url?scp=84861898046&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861898046&partnerID=8YFLogxK

U2 - 10.1152/japplphysiol.01217.2011

DO - 10.1152/japplphysiol.01217.2011

M3 - Article

C2 - 22461441

AN - SCOPUS:84861898046

VL - 112

SP - 1875

EP - 1883

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 0161-7567

IS - 11

ER -