Effects of exercise pressor reflex activation on carotid baroreflex function during exercise in humans

K. M. Gallagher, P. J. Fadel, M. Strømstad, K. Ide, S. A. Smith, R. G. Querry, P. B. Raven, N. H. Secher

Research output: Contribution to journalArticle

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Abstract

1. This investigation was designed to determine the contribution of the exercise pressor reflex to the resetting of the carotid baroreflex during exercise. 2. Ten subjects performed 3.5 min of static one-legged exercise (20% maximal voluntary contraction) and 7 min dynamic cycling (20% maximal oxygen uptake) under two conditions: control (no intervention) and with the application of medical anti-shock (MAS) trousers inflated to 100 mmHg (to activate the exercise pressor reflex). Carotid baroreflex function was determined at rest and during exercise using a rapid neck pressure/neck suction technique. 3. During exercise, the application of MAS trousers (MAS condition) increased mean arterial pressure (MAP), plasma noradrenaline concentration (dynamic exercise only) and perceived exertion (dynamic exercise only) when compared to control (P<0.05). No effect of the MAS condition was evident at rest. The MAS condition had no effect on heart rate (HR), plasma lactate and adrenaline concentrations or oxygen uptake at rest and during exercise. The carotid baroreflex stimulus-response curve was reset upward on the response arm and rightward to a higher operating pressure by control exercise without alterations in gain. Activation of the exercise pressor reflex by MAS trousers further reset carotid baroreflex control of MAP, as indicated by the upward and rightward relocation of the curve. However, carotid baroreflex control of HR was only shifted rightward to higher operating pressures by MAS trousers. The sensitivity of the carotid baroreflex was unaltered by exercise pressor reflex activation. 4. These findings suggest that during dynamic and static exercise pressor reflex is capable of actively resetting carotid baroreflex control of mean arterial pressure; however, it would appear only to modulate carotid baroreflex control of heart rate.

Original languageEnglish (US)
Pages (from-to)871-880
Number of pages10
JournalJournal of Physiology
Volume533
Issue number3
DOIs
StatePublished - Jun 15 2001

Fingerprint

Baroreflex
Reflex
Gravity Suits
Shock
Arterial Pressure
Heart Rate
Pressure
Neck
Oxygen
Suction
Epinephrine
Lactic Acid
Norepinephrine
Arm

ASJC Scopus subject areas

  • Physiology

Cite this

Effects of exercise pressor reflex activation on carotid baroreflex function during exercise in humans. / Gallagher, K. M.; Fadel, P. J.; Strømstad, M.; Ide, K.; Smith, S. A.; Querry, R. G.; Raven, P. B.; Secher, N. H.

In: Journal of Physiology, Vol. 533, No. 3, 15.06.2001, p. 871-880.

Research output: Contribution to journalArticle

Gallagher, K. M. ; Fadel, P. J. ; Strømstad, M. ; Ide, K. ; Smith, S. A. ; Querry, R. G. ; Raven, P. B. ; Secher, N. H. / Effects of exercise pressor reflex activation on carotid baroreflex function during exercise in humans. In: Journal of Physiology. 2001 ; Vol. 533, No. 3. pp. 871-880.
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