Effects of haem infusion on biliary secretion of porphyrins, haem and bilirubin in man

L. R. McCormack, H. H. Liem, W. B. Strum, Scott M Grundy, U. Muller-Eberhard

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Abstract

Employing a continuous bile collection, we measured the bile secretion of porphyrins, haem (iron protoporphyrin IX regardless of oxidation state) and bilirubin in five healthy subjects. The baseline values for the flow of porphyrins in the bile were: 4.7±1.9 nmol/h uroporphyrin, 27.3±3.8 nmol/h coproporphyrin and 39.2±11.7 nmol/h protoporphyrin. Bile haem flow was 59.7±12.6 nmol/h, and that of bilirubin 23.8±8.2 μmol/h. Following haem injection (6.4 μmol/kg) the flow of protoporphyrin but not of the other porphyrins was reduced, and the bile haem flow of bilirubin did not increase significantly. A few patients with representative porphyrias showed the expected increase in copro- and protoporphyrin in the bile. The patient with coproporphyria exhibited a bile flow of coproporphyrin of 1470±133 nmol/h and of protoporphyrin of 334±29 nmol/h; haem infusion significantly reduced the bile flow of both porphyrins (to 649±101 for copro- and 215±36 nmol/h for protoporphyrin). The patient with protoporphyria had an increased protoporphyrin flow, yet haem infusion caused no reduction in protoporphyrin flow (106±7 after v. 81.4± 23 nmol/h before haem). In conclusion, we found that haem and porphyrins are normal constituents of bile, and that injected haem appears in bile. Bile bilirubin did not rise within 12 h after haem infusion a finding which warrants further investigation.

Original languageEnglish (US)
Pages (from-to)257-262
Number of pages6
JournalEuropean Journal of Clinical Investigation
Volume12
Issue number3
StatePublished - 1982

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Porphyrins
Heme
Bilirubin
Bile
Coproporphyrins
Uroporphyrins
Patient Advocacy
Porphyrias
protoporphyrin IX
Healthy Volunteers
Oxidation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effects of haem infusion on biliary secretion of porphyrins, haem and bilirubin in man. / McCormack, L. R.; Liem, H. H.; Strum, W. B.; Grundy, Scott M; Muller-Eberhard, U.

In: European Journal of Clinical Investigation, Vol. 12, No. 3, 1982, p. 257-262.

Research output: Contribution to journalArticle

McCormack, LR, Liem, HH, Strum, WB, Grundy, SM & Muller-Eberhard, U 1982, 'Effects of haem infusion on biliary secretion of porphyrins, haem and bilirubin in man', European Journal of Clinical Investigation, vol. 12, no. 3, pp. 257-262.
McCormack, L. R. ; Liem, H. H. ; Strum, W. B. ; Grundy, Scott M ; Muller-Eberhard, U. / Effects of haem infusion on biliary secretion of porphyrins, haem and bilirubin in man. In: European Journal of Clinical Investigation. 1982 ; Vol. 12, No. 3. pp. 257-262.
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abstract = "Employing a continuous bile collection, we measured the bile secretion of porphyrins, haem (iron protoporphyrin IX regardless of oxidation state) and bilirubin in five healthy subjects. The baseline values for the flow of porphyrins in the bile were: 4.7±1.9 nmol/h uroporphyrin, 27.3±3.8 nmol/h coproporphyrin and 39.2±11.7 nmol/h protoporphyrin. Bile haem flow was 59.7±12.6 nmol/h, and that of bilirubin 23.8±8.2 μmol/h. Following haem injection (6.4 μmol/kg) the flow of protoporphyrin but not of the other porphyrins was reduced, and the bile haem flow of bilirubin did not increase significantly. A few patients with representative porphyrias showed the expected increase in copro- and protoporphyrin in the bile. The patient with coproporphyria exhibited a bile flow of coproporphyrin of 1470±133 nmol/h and of protoporphyrin of 334±29 nmol/h; haem infusion significantly reduced the bile flow of both porphyrins (to 649±101 for copro- and 215±36 nmol/h for protoporphyrin). The patient with protoporphyria had an increased protoporphyrin flow, yet haem infusion caused no reduction in protoporphyrin flow (106±7 after v. 81.4± 23 nmol/h before haem). In conclusion, we found that haem and porphyrins are normal constituents of bile, and that injected haem appears in bile. Bile bilirubin did not rise within 12 h after haem infusion a finding which warrants further investigation.",
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N2 - Employing a continuous bile collection, we measured the bile secretion of porphyrins, haem (iron protoporphyrin IX regardless of oxidation state) and bilirubin in five healthy subjects. The baseline values for the flow of porphyrins in the bile were: 4.7±1.9 nmol/h uroporphyrin, 27.3±3.8 nmol/h coproporphyrin and 39.2±11.7 nmol/h protoporphyrin. Bile haem flow was 59.7±12.6 nmol/h, and that of bilirubin 23.8±8.2 μmol/h. Following haem injection (6.4 μmol/kg) the flow of protoporphyrin but not of the other porphyrins was reduced, and the bile haem flow of bilirubin did not increase significantly. A few patients with representative porphyrias showed the expected increase in copro- and protoporphyrin in the bile. The patient with coproporphyria exhibited a bile flow of coproporphyrin of 1470±133 nmol/h and of protoporphyrin of 334±29 nmol/h; haem infusion significantly reduced the bile flow of both porphyrins (to 649±101 for copro- and 215±36 nmol/h for protoporphyrin). The patient with protoporphyria had an increased protoporphyrin flow, yet haem infusion caused no reduction in protoporphyrin flow (106±7 after v. 81.4± 23 nmol/h before haem). In conclusion, we found that haem and porphyrins are normal constituents of bile, and that injected haem appears in bile. Bile bilirubin did not rise within 12 h after haem infusion a finding which warrants further investigation.

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