Effects of hormone replacement therapy on plasma homocysteine and C-reactive protein levels

Aylin Yildirir, Funda Aybar, Lale Tokgozoglu, Hakan Yarali, Giray Kabakci, Orhan Bukulmez, Incilay Sinici, Ali Oto

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

In order to investigate the effect of hormone replacement therapy (HRT) on plasma homocysteine and C-reactive protein (CRP) levels 46 healthy postmenopausal women were prospectively enrolled. HRT, which was either 0.625 mg/day conjugated equine estrogen (CEE) plus 2.5 mg/day medroxyprogesterone acetate (MPA) or 0.625 mg/day CEE alone were administered. After 6 months, estrogen alone significantly increased serum CRP concentrations (p =0.039), however, estrogen plus progesterone therapy did not significantly alter serum CRP levels. Both regimens significantly decreased plasma homocysteine levels (CEE group p =0.034, CEE +MPA group p =0.007). It was concluded that the reduction in plasma homocysteine levels with both regimens might contribute to the cardiovascular benefit of HRT and the CRP raising effect of estrogen might be partially prevented by the addition of progesterone.

Original languageEnglish (US)
Pages (from-to)54-58
Number of pages5
JournalGynecologic and Obstetric Investigation
Volume53
Issue number1
DOIs
StatePublished - Feb 11 2002

Keywords

  • C-reactive protein
  • Homocysteine
  • Hormone replacement therapy
  • Menopause

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'Effects of hormone replacement therapy on plasma homocysteine and C-reactive protein levels'. Together they form a unique fingerprint.

  • Cite this