Effects of in vivo cocaine administration on human platelet aggregation

Christian M. Heesch, Brian H. Negus, Manfred Steiner, Richard W. Snyder, Donald D. McIntire, Paul A. Grayburn Md, Joy Ashcraft, José A. Hernández, Eric J. Eichhorn

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

To evaluate whether cocaine administration to human volunteers in vivo increases platelet aggregation, 12 healthy male volunteers were studied twice in a prospective, double-blinded fashion. There was a decrease in aggregation following cocaine exposure compared to placebo, which was most prominent at high doses of adenosine diphosphate.

Original languageEnglish (US)
Pages (from-to)237-239
Number of pages3
JournalAmerican Journal of Cardiology
Volume78
Issue number2
DOIs
StatePublished - Jul 15 1996

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Heesch, C. M., Negus, B. H., Steiner, M., Snyder, R. W., McIntire, D. D., Grayburn Md, P. A., Ashcraft, J., Hernández, J. A., & Eichhorn, E. J. (1996). Effects of in vivo cocaine administration on human platelet aggregation. American Journal of Cardiology, 78(2), 237-239. https://doi.org/10.1016/S0002-9149(96)00267-6